Interferons Regulate the Phenotype of  Wild-type and Mutant Herpes Simplex Viruses In Vivo

Mechanisms responsible for neuroattenuation of herpes simplex virus (HSV) have been defined previously by studies of mutant viruses in cultured cells. The hypothesis that null mutations in host genes can override the attenuated phenotype of null mutations in certain viral genes was tested. Mutants s...

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Bibliographic Details
Main Authors: Leib, David A., Harrison, Travis E., Laslo, Kathleen M., Machalek, Michael A., Moorman, Nathaniel J., Virgin, Herbert W.
Format: Online
Language:English
Published: The Rockefeller University Press 1999
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192939/