Reconstitution of T cell receptor signaling in ZAP-70-deficient cells by retroviral transduction of the ZAP-70 gene
A variant of severe combined immunodeficiency syndrome (SCID) with a selective inability to produce CD8 single positive T cells and a signal transduction defect in peripheral CD4+ cells has recently been shown to be the result of mutations in the ZAP-70 gene. T cell receptor (TCR) signaling requires...
| Format: | Online |
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| Language: | English |
| Published: |
The Rockefeller University Press
1996
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192882/ |