Anergic T cells are defective in both jun NH2-terminal kinase and mitogen-activated protein kinase signaling pathways
T helper type 1 cells (Th1) become anergic when stimulated through the antigen receptor in the absence of costimulation. They do not produce IL-2 or proliferate in response to subsequent stimulation. Previous studies have indicated that anergic T cells are defective in the trnsactivational activity...
| Format: | Online |
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| Language: | English |
| Published: |
The Rockefeller University Press
1996
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192566/ |