Comparison of somatic mutation frequency among immunoglobulin genes
We analyzed the frequency of somatic mutation in immunoglobulin genes from hybridomas that secrete anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) monoclonal antibodies. A high frequency of mutation (3.3-4.4%) was observed in both the rearranged VH186.2 and V lambda 1 genes, indicating that somatic mutati...
| Format: | Online |
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| Language: | English |
| Published: |
The Rockefeller University Press
1994
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2191348/ |