Δn89β-Catenin Induces Precocious Development, Differentiation, and Neoplasia in Mammary Gland

To investigate the role of β-catenin in mammary gland development and neoplasia, we expressed a stabilized, transcriptionally active form of β-catenin lacking the NH2-terminal 89 amino acids (ΔN89β-catenin) under the control of the mouse mammary tumor virus long terminal repeat. Our results show tha...

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Bibliographic Details
Main Authors: Imbert, Alexandra, Eelkema, Rachel, Jordan, Sara, Feiner, Helen, Cowin, Pamela
Format: Online
Language:English
Published: The Rockefeller University Press 2001
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190562/