Cellular basis of neonatal induction of in vitro tolerance

Cellular basis of neonatal induction of in vitro tolerance

The LD and SD antigens of the major histocompatibility complex subserve differential roles in the induction of the proliferative phase in mixed lymphocyte culture and in the cytotoxic reaction seen in cell-mediated lympholysis. The present study suggests that they also behave differently in the neon...

Full description

Bibliographic Details
Format: Online
Language:English
Published: The Rockefeller University Press 1976
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190225/
id pubmed-2190225
recordtype oai_dc
spelling pubmed-21902252008-04-17 Cellular basis of neonatal induction of in vitro tolerance Articles The LD and SD antigens of the major histocompatibility complex subserve differential roles in the induction of the proliferative phase in mixed lymphocyte culture and in the cytotoxic reaction seen in cell-mediated lympholysis. The present study suggests that they also behave differently in the neonatal induction of tolerance. SD antigens appear to induce tolerance in the cytotoxic T lymphocytes very effectively, whereas LD antigens (or the cytotoxic targets coded by genes in the I and/or S regions) are relatively ineffective in this regard. LD antigens presented neonatally are effective at inducing tolerance in the proliferating helper cells. The Rockefeller University Press 1976-06-01 /pmc/articles/PMC2190225/ /pubmed/1083892 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
title Cellular basis of neonatal induction of in vitro tolerance
spellingShingle Cellular basis of neonatal induction of in vitro tolerance
title_short Cellular basis of neonatal induction of in vitro tolerance
title_full Cellular basis of neonatal induction of in vitro tolerance
title_fullStr Cellular basis of neonatal induction of in vitro tolerance
title_full_unstemmed Cellular basis of neonatal induction of in vitro tolerance
title_sort cellular basis of neonatal induction of in vitro tolerance
description The LD and SD antigens of the major histocompatibility complex subserve differential roles in the induction of the proliferative phase in mixed lymphocyte culture and in the cytotoxic reaction seen in cell-mediated lympholysis. The present study suggests that they also behave differently in the neonatal induction of tolerance. SD antigens appear to induce tolerance in the cytotoxic T lymphocytes very effectively, whereas LD antigens (or the cytotoxic targets coded by genes in the I and/or S regions) are relatively ineffective in this regard. LD antigens presented neonatally are effective at inducing tolerance in the proliferating helper cells.
publisher The Rockefeller University Press
publishDate 1976
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190225/
_version_ 1611429259256004608

Similar Items