Mature bone marrow erythroid burst-forming units do not require T cells for induction of erythropoietin-dependent differentiation
Cell-cell interactions between mature T cells and peripheral blood null cells induce erythropoietin-stimulated differentiation of peripheral blood-derived erythroid progenitors. By the use of complement-fixing cytolytic murine hybridoma and antibody uniquely reactive with mature T lymphocytes, this...
| Format: | Online |
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| Language: | English |
| Published: |
The Rockefeller University Press
1980
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185951/ |
| Summary: | Cell-cell interactions between mature T cells and peripheral blood null cells induce erythropoietin-stimulated differentiation of peripheral blood-derived erythroid progenitors. By the use of complement-fixing cytolytic murine hybridoma and antibody uniquely reactive with mature T lymphocytes, this dependence of immature peripheral blood erythroid burst-forming unit (BFU-E) differentiation upon mature T cells or a T cell conditioned medium is confirmed. By using the same antibody, it is demonstrated that the differentiation of mature bone marrow BFU-E does not require either mature T cells or lymphocyte mitogenic factor. These findings do not preclude the presence in the bone marrow of other cells, perhaps even immature T cells, that influence erythropoietin- dependent erythroid differentiation of mature marrow BFU-E. |
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