Agrin-Induced Phosphorylation of the Acetylcholine Receptor Regulates Cytoskeletal Anchoring and Clustering

At the developing neuromuscular junction, a motoneuron-derived factor called agrin signals through the muscle-specific kinase receptor to induce postsynaptic aggregation of the acetylcholine receptor (AChR). The agrin signaling pathway involves tyrosine phosphorylation of the AChR β subunit, and we...

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Bibliographic Details
Main Authors: Borges, Lúcia S., Ferns, Michael
Format: Online
Language:English
Published: The Rockefeller University Press 2001
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185523/