Determinants of the Nuclear Localization of the Heterodimeric DNA Fragmentation Factor (Icad/Cad)

Determinants of the Nuclear Localization of the Heterodimeric DNA Fragmentation Factor (Icad/Cad)

Programmed cell death or apoptosis leads to the activation of the caspase-activated DNase (CAD), which degrades chromosomal DNA into nucleosomal fragments. Biochemical studies revealed that CAD forms an inactive heterodimer with the inhibitor of caspase-activated DNase (ICAD), or its alternatively s...

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Bibliographic Details
Main Authors: Lechardeur, Delphine, Drzymala, Luke, Sharma, Manu, Zylka, Danuta, Kinach, Robert, Pacia, Joanna, Hicks, Christopher, Usmani, Nawaid, Rommens, Johanna M., Lukacs, Gergely L.
Format: Online
Language:English
Published: The Rockefeller University Press 2000
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180231/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180231/

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