In the Era of Systematic Reviews, Does the Size of an Individual Trial Still Matter?

Background to the debate: Systematic reviews that combine high-quality evidence from several trials are now widely considered to be at the top of the hierarchy of clinical evidence. Given the primacy of systematic reviews—and the fact that individual clinical trials rarely provide definitive answers...

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Bibliographic Details
Main Authors: Guyatt, Gordon H, Mills, Edward J, Elbourne, Diana
Format: Online
Language:English
Published: Public Library of Science 2008
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174963/