P0 Glycoprotein Overexpression Causes Congenital Hypomyelination of Peripheral Nerves

P0 Glycoprotein Overexpression Causes Congenital Hypomyelination of Peripheral Nerves

We show that normal peripheral nerve myelination depends on strict dosage of the most abundantly expressed myelin gene, myelin protein zero (Mpz). Transgenic mice containing extra copies of Mpz manifested a dose-dependent, dysmyelinating neuropathy, ranging from transient perinatal hypomyelination t...

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Bibliographic Details
Main Authors: Wrabetz, Lawrence, Feltri, Maria Laura, Quattrini, Angelo, Imperiale, Daniele, Previtali, Stefano, D'Antonio, Maurizio, Martini, Rudolf, Yin, Xinghua, Trapp, Bruce D., Zhou, Lei, Chiu, Shing-Yan, Messing, Albee
Format: Online
Language:English
Published: The Rockefeller University Press 2000
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174542/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174542/

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