Processing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements

Processing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements

Glypican (GPC)-3 inhibits cell proliferation and regulates cell survival during development. This action is demonstrated by GPC3 loss-of-function mutations in humans and mice. Here, we show that the GPC3 core protein is processed by a furinlike convertase. This processing is essential for GPC3 modul...

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Bibliographic Details
Main Authors: De Cat, Bart, Muyldermans, Sin-Ya, Coomans, Christien, Degeest, Gisèle, Vanderschueren, Bernadette, Creemers, John, Biemar, Frédéric, Peers, Bernard, David, Guido
Format: Online
Language:English
Published: The Rockefeller University Press 2003
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173654/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173654/

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