The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP–dependent activation of TGF-β1

The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP–dependent activation of TGF-β1

Întegrins, matrix metalloproteases (MMPs), and the cytokine TGF-β have each been implicated in homeostatic cell behaviors such as cell growth and matrix remodeling. TGF-β exists mainly in a latent state, and a major point of homeostatic control is the activation of TGF-β. Because the latent domain o...

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Bibliographic Details
Main Authors: Mu, Dezhi, Cambier, Stephanie, Fjellbirkeland, Lars, Baron, Jody L., Munger, John S., Kawakatsu, Hisaaki, Sheppard, Dean, Broaddus, V. Courtney, Nishimura, Stephen L.
Format: Online
Language:English
Published: The Rockefeller University Press 2002
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173277/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173277/

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