Defective Rac-mediated proliferation and survival after targeted mutation of the β1 integrin cytodomain

Defective Rac-mediated proliferation and survival after targeted mutation of the β1 integrin cytodomain

Cell matrix adhesion is required for cell proliferation and survival. Here we report that mutation by gene targeting of the cytoplasmic tail of β1 integrin leads to defective proliferation and survival both in vivo and in vitro. Primary murine embryonic fibroblasts (MEFs) derived from mutant homozyg...

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Bibliographic Details
Main Authors: Hirsch, Emilio, Barberis, Laura, Brancaccio, Mara, Azzolino, Ornella, Xu, Dazhong, Kyriakis, John M., Silengo, Lorenzo, Giancotti, Filippo G., Tarone, Guido, Fässler, Reinhard, Altruda, Fiorella
Format: Online
Language:English
Published: The Rockefeller University Press 2002
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173276/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173276/

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