Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway
The protective antigen (PA) of anthrax toxin binds to a cell surface receptor, undergoes heptamerization, and binds the enzymatic subunits, the lethal factor (LF) and the edema factor (EF). The resulting complex is then endocytosed. Via mechanisms that depend on the vacuolar ATPase and require membr...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
The Rockefeller University Press
2004
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172425/ |