Differential transactivation of sphingosine-1-phosphate receptors modulates NGF-induced neurite extension

Differential transactivation of sphingosine-1-phosphate receptors modulates NGF-induced neurite extension

The process of neurite extension after activation of the TrkA tyrosine kinase receptor by nerve growth factor (NGF) involves complex signaling pathways. Stimulation of sphingosine kinase 1 (SphK1), the enzyme that phosphorylates sphingosine to form sphingosine-1-phosphate (S1P), is part of the funct...

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Bibliographic Details
Main Authors: Toman, Rachelle E., Payne, Shawn G., Watterson, Kenneth R., Maceyka, Michael, Lee, Norman H., Milstien, Sheldon, Bigbee, John W., Spiegel, Sarah
Format: Online
Language:English
Published: The Rockefeller University Press 2004
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172260/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172260/

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