X chromosome choice occurs independently of asynchronous replication timing

In mammals, dosage compensation is achieved by X chromosome inactivation in female cells. Xist is required and sufficient for X inactivation, and Xist gene deletions result in completely skewed X inactivation. In this work, we analyzed skewing of X inactivation in mice with an Xist deletion encompas...

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Bibliographic Details
Main Authors: Gribnau, Joost, Luikenhuis, Sandra, Hochedlinger, Konrad, Monkhorst, Kim, Jaenisch, Rudolf
Format: Online
Language:English
Published: The Rockefeller University Press 2005
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171734/