Matrix Gla Protein Is a Developmental Regulator of Chondrocyte Mineralization And, When Constitutively Expressed, Blocks Endochondral and Intramembranous Ossification in the Limb

Matrix Gla Protein Is a Developmental Regulator of Chondrocyte Mineralization And, When Constitutively Expressed, Blocks Endochondral and Intramembranous Ossification in the Limb

Matrix GLA protein (MGP), a γ-carboxyglutamic acid (GLA)–rich, vitamin K–dependent and apatite-binding protein, is a regulator of hypertrophic cartilage mineralization during development. However, MGP is produced by both hypertrophic and immature chondrocytes, suggesting that MGP's role in mine...

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Bibliographic Details
Main Authors: Yagami, Kimitoshi, Suh, Jo-Young, Enomoto-Iwamoto, Motomi, Koyama, Eiki, Abrams, William R., Shapiro, Irving M., Pacifici, Maurizio, Iwamoto, Masahiro
Format: Online
Language:English
Published: The Rockefeller University Press 1999
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169349/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169349/

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