The Two ATP Binding Sites of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Play Distinct Roles in Gating Kinetics and Energetics

The Two ATP Binding Sites of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Play Distinct Roles in Gating Kinetics and Energetics

Cystic fibrosis transmembrane conductance regulator (CFTR), a member of the ABC (ATP binding cassette) transporter family, is a chloride channel whose activity is controlled by protein kinase–dependent phosphorylation. Opening and closing (gating) of the phosphorylated CFTR is coupled to ATP binding...

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Bibliographic Details
Main Authors: Zhou, Zhen, Wang, Xiaohui, Liu, Hao-Yang, Zou, Xiaoqin, Li, Min, Hwang, Tzyh-Chang
Format: Online
Language:English
Published: The Rockefeller University Press 2006
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151577/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151577/

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