EGF-R signaling through Fyn kinase disrupts the function of integrin α6β4 at hemidesmosomes: role in epithelial cell migration and carcinoma invasion

EGF-R signaling through Fyn kinase disrupts the function of integrin α6β4 at hemidesmosomes: role in epithelial cell migration and carcinoma invasion

We have examined the mechanism and functional significance of hemidesmosome disassembly during normal epithelial cell migration and squamous carcinoma invasion. Our findings indicate that a fraction of EGF receptor (EGF-R) combines with the hemidesmosomal integrin α6β4 in both normal and neoplastic...

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Bibliographic Details
Main Authors: Mariotti, Agnese, Kedeshian, Paul A., Dans, Michael, Curatola, Anna Maria, Gagnoux-Palacios, Laurent, Giancotti, Filippo G.
Format: Online
Language:English
Published: The Rockefeller University Press 2001
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150849/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150849/

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