ANTIGENIC SPECIFICITIES ON MURINE SARCOMA CELLS : RECIPROCAL RELATIONSHIP BETWEEN NORMAL TRANSPLANTATION ANTIGENS (H-2) AND TUMOR-SPECIFIC IMMUNOGENICITY

Five methylcholanthrene-induced sarcomas were compared for their capacity to (a) absorb monospecific H-2 antisera, (b) induce tumor-specific immunity in syngeneic mice, and (c) metastasize early to the lungs. Comparison of the uptakes of monospecific H-2 antisera by the five different tumors showed...

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Main Authors:	Haywood, Gerald R., McKhann, Charles F.
Format:	Online
Language:	English
Published:	The Rockefeller University Press 1971
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138927/

id	pubmed-2138927
recordtype	oai_dc
spelling	pubmed-21389272008-04-17 ANTIGENIC SPECIFICITIES ON MURINE SARCOMA CELLS : RECIPROCAL RELATIONSHIP BETWEEN NORMAL TRANSPLANTATION ANTIGENS (H-2) AND TUMOR-SPECIFIC IMMUNOGENICITY Haywood, Gerald R. McKhann, Charles F. Article Five methylcholanthrene-induced sarcomas were compared for their capacity to (a) absorb monospecific H-2 antisera, (b) induce tumor-specific immunity in syngeneic mice, and (c) metastasize early to the lungs. Comparison of the uptakes of monospecific H-2 antisera by the five different tumors showed that each of the tumors had a high, intermediate, or low surface representation of all of the seven specificities tested. No antigenic specificity was completely absent from any tumor, and no tumor had an unusually large or small amount of any individual specificity. The tumors could be placed in the sequence from one to five with respect to their H-2 antigenicity. The same five tumors were also ranked with respect to their capacity to induce a tumor-specific immune response in syngeneic mice. The tumor-specific immunogenicity had an inverse relationship to the H-2 antigenicity in that highly immunogenic tumors were those that had quantitatively less H-2 antigen on their surface and vice versa. Early metastases to the lung was associated with low levels of tumor-specific immunogenicity and high levels of H-2 antigenicity. The Rockefeller University Press 1971-06-01 /pmc/articles/PMC2138927/ /pubmed/5576331 Text en Copyright © 1971 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Haywood, Gerald R. McKhann, Charles F.
spellingShingle	Haywood, Gerald R. McKhann, Charles F. ANTIGENIC SPECIFICITIES ON MURINE SARCOMA CELLS : RECIPROCAL RELATIONSHIP BETWEEN NORMAL TRANSPLANTATION ANTIGENS (H-2) AND TUMOR-SPECIFIC IMMUNOGENICITY
author_facet	Haywood, Gerald R. McKhann, Charles F.
author_sort	Haywood, Gerald R.
title	ANTIGENIC SPECIFICITIES ON MURINE SARCOMA CELLS : RECIPROCAL RELATIONSHIP BETWEEN NORMAL TRANSPLANTATION ANTIGENS (H-2) AND TUMOR-SPECIFIC IMMUNOGENICITY
title_short	ANTIGENIC SPECIFICITIES ON MURINE SARCOMA CELLS : RECIPROCAL RELATIONSHIP BETWEEN NORMAL TRANSPLANTATION ANTIGENS (H-2) AND TUMOR-SPECIFIC IMMUNOGENICITY
title_full	ANTIGENIC SPECIFICITIES ON MURINE SARCOMA CELLS : RECIPROCAL RELATIONSHIP BETWEEN NORMAL TRANSPLANTATION ANTIGENS (H-2) AND TUMOR-SPECIFIC IMMUNOGENICITY
title_fullStr	ANTIGENIC SPECIFICITIES ON MURINE SARCOMA CELLS : RECIPROCAL RELATIONSHIP BETWEEN NORMAL TRANSPLANTATION ANTIGENS (H-2) AND TUMOR-SPECIFIC IMMUNOGENICITY
title_full_unstemmed	ANTIGENIC SPECIFICITIES ON MURINE SARCOMA CELLS : RECIPROCAL RELATIONSHIP BETWEEN NORMAL TRANSPLANTATION ANTIGENS (H-2) AND TUMOR-SPECIFIC IMMUNOGENICITY
title_sort	antigenic specificities on murine sarcoma cells : reciprocal relationship between normal transplantation antigens (h-2) and tumor-specific immunogenicity
description	Five methylcholanthrene-induced sarcomas were compared for their capacity to (a) absorb monospecific H-2 antisera, (b) induce tumor-specific immunity in syngeneic mice, and (c) metastasize early to the lungs. Comparison of the uptakes of monospecific H-2 antisera by the five different tumors showed that each of the tumors had a high, intermediate, or low surface representation of all of the seven specificities tested. No antigenic specificity was completely absent from any tumor, and no tumor had an unusually large or small amount of any individual specificity. The tumors could be placed in the sequence from one to five with respect to their H-2 antigenicity. The same five tumors were also ranked with respect to their capacity to induce a tumor-specific immune response in syngeneic mice. The tumor-specific immunogenicity had an inverse relationship to the H-2 antigenicity in that highly immunogenic tumors were those that had quantitatively less H-2 antigen on their surface and vice versa. Early metastases to the lung was associated with low levels of tumor-specific immunogenicity and high levels of H-2 antigenicity.
publisher	The Rockefeller University Press
publishDate	1971
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138927/
_version_	1611421440423231488

ANTIGENIC SPECIFICITIES ON MURINE SARCOMA CELLS : RECIPROCAL RELATIONSHIP BETWEEN NORMAL TRANSPLANTATION ANTIGENS (H-2) AND TUMOR-SPECIFIC IMMUNOGENICITY

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