THE MEDIATOR OF CELLULAR IMMUNITY : II. MIGRATION OF IMMUNOLOGICALLY COMMITTED LYMPHOCYTES INTO INFLAMMATORY EXUDATES

Peritoneal exudates from rats which have survived an infection with L. monocytogenes can protect cyclophosphamide-treated recipients against a Listeria challenge. They are more effective in this respect than cells obtained from the spleen or thoracic duct lymph. Since exudate cells from normal rats...

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Main Authors:	Koster, F. T., McGregor, D. D., Mackaness, G. B.
Format:	Online
Language:	English
Published:	The Rockefeller University Press 1971
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138894/

id	pubmed-2138894
recordtype	oai_dc
spelling	pubmed-21388942008-04-17 THE MEDIATOR OF CELLULAR IMMUNITY : II. MIGRATION OF IMMUNOLOGICALLY COMMITTED LYMPHOCYTES INTO INFLAMMATORY EXUDATES Koster, F. T. McGregor, D. D. Mackaness, G. B. Article Peritoneal exudates from rats which have survived an infection with L. monocytogenes can protect cyclophosphamide-treated recipients against a Listeria challenge. They are more effective in this respect than cells obtained from the spleen or thoracic duct lymph. Since exudate cells from normal rats and inocula prepared from the resident peritoneal cell populations of infected donors are unable to inhibit the challenge infection, the protective cells must belong to a class of lymphocytes that emerges from the blood in response to inflammation. It is significant therefore that thoracic duct lymphocytes formed during an acute Listeria infection can move into exudates induced by a variety of inflammatory stimuli. The affinity of newly formed lymphocytes for inflamed tissue points to a mechanism whereby the host marshalls its cellular defenses at sites of bacterial invasion. The tendency of short-lived lymphocytes to leave inflamed vessels might also explain their short-circulating life-span. The Rockefeller University Press 1971-01-31 /pmc/articles/PMC2138894/ /pubmed/5002522 Text en Copyright © 1971 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Koster, F. T. McGregor, D. D. Mackaness, G. B.
spellingShingle	Koster, F. T. McGregor, D. D. Mackaness, G. B. THE MEDIATOR OF CELLULAR IMMUNITY : II. MIGRATION OF IMMUNOLOGICALLY COMMITTED LYMPHOCYTES INTO INFLAMMATORY EXUDATES
author_facet	Koster, F. T. McGregor, D. D. Mackaness, G. B.
author_sort	Koster, F. T.
title	THE MEDIATOR OF CELLULAR IMMUNITY : II. MIGRATION OF IMMUNOLOGICALLY COMMITTED LYMPHOCYTES INTO INFLAMMATORY EXUDATES
title_short	THE MEDIATOR OF CELLULAR IMMUNITY : II. MIGRATION OF IMMUNOLOGICALLY COMMITTED LYMPHOCYTES INTO INFLAMMATORY EXUDATES
title_full	THE MEDIATOR OF CELLULAR IMMUNITY : II. MIGRATION OF IMMUNOLOGICALLY COMMITTED LYMPHOCYTES INTO INFLAMMATORY EXUDATES
title_fullStr	THE MEDIATOR OF CELLULAR IMMUNITY : II. MIGRATION OF IMMUNOLOGICALLY COMMITTED LYMPHOCYTES INTO INFLAMMATORY EXUDATES
title_full_unstemmed	THE MEDIATOR OF CELLULAR IMMUNITY : II. MIGRATION OF IMMUNOLOGICALLY COMMITTED LYMPHOCYTES INTO INFLAMMATORY EXUDATES
title_sort	mediator of cellular immunity : ii. migration of immunologically committed lymphocytes into inflammatory exudates
description	Peritoneal exudates from rats which have survived an infection with L. monocytogenes can protect cyclophosphamide-treated recipients against a Listeria challenge. They are more effective in this respect than cells obtained from the spleen or thoracic duct lymph. Since exudate cells from normal rats and inocula prepared from the resident peritoneal cell populations of infected donors are unable to inhibit the challenge infection, the protective cells must belong to a class of lymphocytes that emerges from the blood in response to inflammation. It is significant therefore that thoracic duct lymphocytes formed during an acute Listeria infection can move into exudates induced by a variety of inflammatory stimuli. The affinity of newly formed lymphocytes for inflamed tissue points to a mechanism whereby the host marshalls its cellular defenses at sites of bacterial invasion. The tendency of short-lived lymphocytes to leave inflamed vessels might also explain their short-circulating life-span.
publisher	The Rockefeller University Press
publishDate	1971
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138894/
_version_	1611421421778501632

THE MEDIATOR OF CELLULAR IMMUNITY : II. MIGRATION OF IMMUNOLOGICALLY COMMITTED LYMPHOCYTES INTO INFLAMMATORY EXUDATES

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