STUDIES OF THE Vi (γ2c) SUBGROUP OF γ-GLOBULIN : A RELATIONSHIP BETWEEN CONCENTRATION AND GENETIC TYPE AMONG NORMAL INDIVIDUALS

Further delineation of the antigens characteristic of the Vi or γ2c subgroup of γ-globulin was carried out utilizing a number of rabbit and primate antisera. Two genetic antigens characteristic of this subgroup, Gm(b) and Gm(g), were also detected by precipitation techniques with certain of the ant...

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Main Authors:	Yount, William J., Kunkel, Henry G., Litwin, Stephen D.
Format:	Online
Language:	English
Published:	The Rockefeller University Press 1967
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138342/

id	pubmed-2138342
recordtype	oai_dc
spelling	pubmed-21383422008-04-17 STUDIES OF THE Vi (γ2c) SUBGROUP OF γ-GLOBULIN : A RELATIONSHIP BETWEEN CONCENTRATION AND GENETIC TYPE AMONG NORMAL INDIVIDUALS Yount, William J. Kunkel, Henry G. Litwin, Stephen D. Article Further delineation of the antigens characteristic of the Vi or γ2c subgroup of γ-globulin was carried out utilizing a number of rabbit and primate antisera. Two genetic antigens characteristic of this subgroup, Gm(b) and Gm(g), were also detected by precipitation techniques with certain of the antisera. These were clearly differentiated from antigens common to all proteins of this subgroup. The concentration, of Vi protein in normal and pathological sera from several population groups was measured quantitatively utilizing a variety of immunological procedures. All sera studied showed measurable levels. The mean value for Caucasian sera was 1.06 mg/ml, representing approximately 8% of γG-globulin. This agreed closely with a figure of 8.4% for the incidence of myeloma proteins of the Vi subgroup among all γG-myeloma proteins in Caucasians. A relationship was found between the Vi subgroup concentration and the specific genetic type of a given individual. Measurements of the Gm(b) genetic determinants, which are found solely in Vi-type proteins, brought forward this relationship. Gm(b+) individuals showed higher concentrations of Vi-type γ-globulin than those who were Gm(b-), and this difference was statistically significant for both the homozygous and heterozygous states. It appeared that the structural genes for Gm(b+) polypeptide chains showed a greater synthetic capacity than those for Gm(b-) types. The possible significance of such effects in governing the relative composition of the antibody population in a given individual is discussed. The Rockefeller University Press 1967-01-01 /pmc/articles/PMC2138342/ /pubmed/4163358 Text en Copyright © 1967 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Yount, William J. Kunkel, Henry G. Litwin, Stephen D.
spellingShingle	Yount, William J. Kunkel, Henry G. Litwin, Stephen D. STUDIES OF THE Vi (γ2c) SUBGROUP OF γ-GLOBULIN : A RELATIONSHIP BETWEEN CONCENTRATION AND GENETIC TYPE AMONG NORMAL INDIVIDUALS
author_facet	Yount, William J. Kunkel, Henry G. Litwin, Stephen D.
author_sort	Yount, William J.
title	STUDIES OF THE Vi (γ2c) SUBGROUP OF γ-GLOBULIN : A RELATIONSHIP BETWEEN CONCENTRATION AND GENETIC TYPE AMONG NORMAL INDIVIDUALS
title_short	STUDIES OF THE Vi (γ2c) SUBGROUP OF γ-GLOBULIN : A RELATIONSHIP BETWEEN CONCENTRATION AND GENETIC TYPE AMONG NORMAL INDIVIDUALS
title_full	STUDIES OF THE Vi (γ2c) SUBGROUP OF γ-GLOBULIN : A RELATIONSHIP BETWEEN CONCENTRATION AND GENETIC TYPE AMONG NORMAL INDIVIDUALS
title_fullStr	STUDIES OF THE Vi (γ2c) SUBGROUP OF γ-GLOBULIN : A RELATIONSHIP BETWEEN CONCENTRATION AND GENETIC TYPE AMONG NORMAL INDIVIDUALS
title_full_unstemmed	STUDIES OF THE Vi (γ2c) SUBGROUP OF γ-GLOBULIN : A RELATIONSHIP BETWEEN CONCENTRATION AND GENETIC TYPE AMONG NORMAL INDIVIDUALS
title_sort	studies of the vi (γ2c) subgroup of γ-globulin : a relationship between concentration and genetic type among normal individuals
description	Further delineation of the antigens characteristic of the Vi or γ2c subgroup of γ-globulin was carried out utilizing a number of rabbit and primate antisera. Two genetic antigens characteristic of this subgroup, Gm(b) and Gm(g), were also detected by precipitation techniques with certain of the antisera. These were clearly differentiated from antigens common to all proteins of this subgroup. The concentration, of Vi protein in normal and pathological sera from several population groups was measured quantitatively utilizing a variety of immunological procedures. All sera studied showed measurable levels. The mean value for Caucasian sera was 1.06 mg/ml, representing approximately 8% of γG-globulin. This agreed closely with a figure of 8.4% for the incidence of myeloma proteins of the Vi subgroup among all γG-myeloma proteins in Caucasians. A relationship was found between the Vi subgroup concentration and the specific genetic type of a given individual. Measurements of the Gm(b) genetic determinants, which are found solely in Vi-type proteins, brought forward this relationship. Gm(b+) individuals showed higher concentrations of Vi-type γ-globulin than those who were Gm(b-), and this difference was statistically significant for both the homozygous and heterozygous states. It appeared that the structural genes for Gm(b+) polypeptide chains showed a greater synthetic capacity than those for Gm(b-) types. The possible significance of such effects in governing the relative composition of the antibody population in a given individual is discussed.
publisher	The Rockefeller University Press
publishDate	1967
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138342/
_version_	1611421096912879616

STUDIES OF THE Vi (γ2c) SUBGROUP OF γ-GLOBULIN : A RELATIONSHIP BETWEEN CONCENTRATION AND GENETIC TYPE AMONG NORMAL INDIVIDUALS

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