IN VITRO DEMONSTRATION OF HUMORAL AND CELL-BOUND IMMUNITY AGAINST COMMON SPECIFIC TRANSPLANTATION ANTIGEN(S) OF ADENOVIRUS 12-INDUCED MOUSE AND HAMSTER TUMORS

IN VITRO DEMONSTRATION OF HUMORAL AND CELL-BOUND IMMUNITY AGAINST COMMON SPECIFIC TRANSPLANTATION ANTIGEN(S) OF ADENOVIRUS 12-INDUCED MOUSE AND HAMSTER TUMORS

A colony inhibition (CI) technique was used to demonstrate in vitro tumor-specific antigenicity common for neoplasms induced by the adenovirus type 12. Immunization of mice against syngeneic mouse adeno 12 tumor cells evoked immunity demonstrable against other adeno 12 neoplasms of mice and of hams...

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Main Authors: Hellström, Ingegerd, Sjögren, Hans O.
Format: Online
Language:English
Published: The Rockefeller University Press 1967
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138280/
id pubmed-2138280
recordtype oai_dc
spelling pubmed-21382802008-04-17 IN VITRO DEMONSTRATION OF HUMORAL AND CELL-BOUND IMMUNITY AGAINST COMMON SPECIFIC TRANSPLANTATION ANTIGEN(S) OF ADENOVIRUS 12-INDUCED MOUSE AND HAMSTER TUMORS Hellström, Ingegerd Sjögren, Hans O. Article A colony inhibition (CI) technique was used to demonstrate in vitro tumor-specific antigenicity common for neoplasms induced by the adenovirus type 12. Immunization of mice against syngeneic mouse adeno 12 tumor cells evoked immunity demonstrable against other adeno 12 neoplasms of mice and of hamster as well. The immunity was detected as antibody activity in the sera of specifically immunized mice and as a similar activity of the lymph node cells of these animals. The finding in transplantation experiments that infection with adenovirus types 12 and 7 induces an isograft immunity against adeno 12 tumors was confirmed by CI tests on the sera of virus-infected mice. The probable identity of the antigen detected by the CI technique and the tumor-specific transplantation antigen is discussed. The Rockefeller University Press 1967-06-01 /pmc/articles/PMC2138280/ /pubmed/4290563 Text en Copyright © 1967 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Hellström, Ingegerd
Sjögren, Hans O.
spellingShingle Hellström, Ingegerd
Sjögren, Hans O.
IN VITRO DEMONSTRATION OF HUMORAL AND CELL-BOUND IMMUNITY AGAINST COMMON SPECIFIC TRANSPLANTATION ANTIGEN(S) OF ADENOVIRUS 12-INDUCED MOUSE AND HAMSTER TUMORS
author_facet Hellström, Ingegerd
Sjögren, Hans O.
author_sort Hellström, Ingegerd
title IN VITRO DEMONSTRATION OF HUMORAL AND CELL-BOUND IMMUNITY AGAINST COMMON SPECIFIC TRANSPLANTATION ANTIGEN(S) OF ADENOVIRUS 12-INDUCED MOUSE AND HAMSTER TUMORS
title_short IN VITRO DEMONSTRATION OF HUMORAL AND CELL-BOUND IMMUNITY AGAINST COMMON SPECIFIC TRANSPLANTATION ANTIGEN(S) OF ADENOVIRUS 12-INDUCED MOUSE AND HAMSTER TUMORS
title_full IN VITRO DEMONSTRATION OF HUMORAL AND CELL-BOUND IMMUNITY AGAINST COMMON SPECIFIC TRANSPLANTATION ANTIGEN(S) OF ADENOVIRUS 12-INDUCED MOUSE AND HAMSTER TUMORS
title_fullStr IN VITRO DEMONSTRATION OF HUMORAL AND CELL-BOUND IMMUNITY AGAINST COMMON SPECIFIC TRANSPLANTATION ANTIGEN(S) OF ADENOVIRUS 12-INDUCED MOUSE AND HAMSTER TUMORS
title_full_unstemmed IN VITRO DEMONSTRATION OF HUMORAL AND CELL-BOUND IMMUNITY AGAINST COMMON SPECIFIC TRANSPLANTATION ANTIGEN(S) OF ADENOVIRUS 12-INDUCED MOUSE AND HAMSTER TUMORS
title_sort in vitro demonstration of humoral and cell-bound immunity against common specific transplantation antigen(s) of adenovirus 12-induced mouse and hamster tumors
description A colony inhibition (CI) technique was used to demonstrate in vitro tumor-specific antigenicity common for neoplasms induced by the adenovirus type 12. Immunization of mice against syngeneic mouse adeno 12 tumor cells evoked immunity demonstrable against other adeno 12 neoplasms of mice and of hamster as well. The immunity was detected as antibody activity in the sera of specifically immunized mice and as a similar activity of the lymph node cells of these animals. The finding in transplantation experiments that infection with adenovirus types 12 and 7 induces an isograft immunity against adeno 12 tumors was confirmed by CI tests on the sera of virus-infected mice. The probable identity of the antigen detected by the CI technique and the tumor-specific transplantation antigen is discussed.
publisher The Rockefeller University Press
publishDate 1967
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138280/
_version_ 1611421059375955968

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