Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7Rα mutant mice

Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7Rα mutant mice

Loss of interleukin (IL)-7 or the IL-7 receptor alpha (IL-7Rα, CD127) results in severe immunodeficiencies in mice and humans. To more precisely identify signals governing IL-7 function in vivo, we have disrupted the IL-7Rα Y449XXM motif in mice by knock-in mutagenesis (IL-7Rα449F). Thymic precursor...

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Bibliographic Details
Main Authors: Osborne, Lisa C., Dhanji, Salim, Snow, Jonathan W., Priatel, John J., Ma, Melissa C., Miners, M. Jill, Teh, Hung-Sia, Goldsmith, Mark A., Abraham, Ninan
Format: Online
Language:English
Published: The Rockefeller University Press 2007
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137912/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137912/

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