Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock

Mammalian 2-Cys peroxiredoxin II (Prx II) is a cellular peroxidase that eliminates endogenous H2O2. The involvement of Prx II in the regulation of lipopolysaccharide (LPS) signaling is poorly understood. In this report, we show that LPS induces substantially enhanced inflammatory events, which inclu...

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Main Authors: Yang, Chul-Su, Lee, Dong-Seok, Song, Chang-Hwa, An, Se-Jin, Li, Shengjin, Kim, Jin-Man, Kim, Cuk Seong, Yoo, Dae Goon, Jeon, Byeong Hwa, Yang, Hee-Young, Lee, Tae-Hoon, Lee, Zee-Won, El-Benna, Jamel, Yu, Dae-Yeul, Jo, Eun-Kyeong
Format: Online
Language:English
Published: The Rockefeller University Press 2007
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137909/