Lack of Foxp3 function and expression in the thymic epithelium
Foxp3 is essential for the commitment of differentiating thymocytes to the regulatory CD4+ T (T reg) cell lineage. In humans and mice with a genetic Foxp3 deficiency, absence of this critical T reg cell population was suggested to be responsible for the severe autoimmune lesions. Recently, it has be...
| Main Authors: | , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
The Rockefeller University Press
2007
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137899/ |