SUPPRESSION OF ANTIBODY SYNTHESIS AND PROLONGATION OF HOMOGRAFT SURVIVAL BY CHLORAMPHENICOL

SUPPRESSION OF ANTIBODY SYNTHESIS AND PROLONGATION OF HOMOGRAFT SURVIVAL BY CHLORAMPHENICOL

Chloramphenicol suppresses primary antibody synthesis in vivo without affecting the ability to develop a normal anamnestic response. Chloramphenicol also prolongs homograft survival in rabbits. The survival of homografts is related to the duration as well as to the amount of chloramphenicol adminis...

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Main Authors: Weisberger, Austin S., Daniel, Thomas M., Hoffman, Allan
Format: Online
Language:English
Published: The Rockefeller University Press 1964
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137731/
id pubmed-2137731
recordtype oai_dc
spelling pubmed-21377312008-04-17 SUPPRESSION OF ANTIBODY SYNTHESIS AND PROLONGATION OF HOMOGRAFT SURVIVAL BY CHLORAMPHENICOL Weisberger, Austin S. Daniel, Thomas M. Hoffman, Allan Article Chloramphenicol suppresses primary antibody synthesis in vivo without affecting the ability to develop a normal anamnestic response. Chloramphenicol also prolongs homograft survival in rabbits. The survival of homografts is related to the duration as well as to the amount of chloramphenicol administered. The mechanism of action of chloramphenicol in suppressing immune responses is correlated with its ability to inhibit protein synthesis in proliferating mammalian cells. These observations suggest that the inhibitory effect of chloramphenicol on protein synthesis may be applicable to mammalian cells in vivo as well as to cell-free systems and to intact mammalian cells in vivo. The Rockefeller University Press 1964-08-01 /pmc/articles/PMC2137731/ /pubmed/19867290 Text en Copyright © 1964 by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Weisberger, Austin S.
Daniel, Thomas M.
Hoffman, Allan
spellingShingle Weisberger, Austin S.
Daniel, Thomas M.
Hoffman, Allan
SUPPRESSION OF ANTIBODY SYNTHESIS AND PROLONGATION OF HOMOGRAFT SURVIVAL BY CHLORAMPHENICOL
author_facet Weisberger, Austin S.
Daniel, Thomas M.
Hoffman, Allan
author_sort Weisberger, Austin S.
title SUPPRESSION OF ANTIBODY SYNTHESIS AND PROLONGATION OF HOMOGRAFT SURVIVAL BY CHLORAMPHENICOL
title_short SUPPRESSION OF ANTIBODY SYNTHESIS AND PROLONGATION OF HOMOGRAFT SURVIVAL BY CHLORAMPHENICOL
title_full SUPPRESSION OF ANTIBODY SYNTHESIS AND PROLONGATION OF HOMOGRAFT SURVIVAL BY CHLORAMPHENICOL
title_fullStr SUPPRESSION OF ANTIBODY SYNTHESIS AND PROLONGATION OF HOMOGRAFT SURVIVAL BY CHLORAMPHENICOL
title_full_unstemmed SUPPRESSION OF ANTIBODY SYNTHESIS AND PROLONGATION OF HOMOGRAFT SURVIVAL BY CHLORAMPHENICOL
title_sort suppression of antibody synthesis and prolongation of homograft survival by chloramphenicol
description Chloramphenicol suppresses primary antibody synthesis in vivo without affecting the ability to develop a normal anamnestic response. Chloramphenicol also prolongs homograft survival in rabbits. The survival of homografts is related to the duration as well as to the amount of chloramphenicol administered. The mechanism of action of chloramphenicol in suppressing immune responses is correlated with its ability to inhibit protein synthesis in proliferating mammalian cells. These observations suggest that the inhibitory effect of chloramphenicol on protein synthesis may be applicable to mammalian cells in vivo as well as to cell-free systems and to intact mammalian cells in vivo.
publisher The Rockefeller University Press
publishDate 1964
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137731/
_version_ 1611420741883920384

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