INVESTIGATIONS CONCERNING THE CHANGES IN SERUM PROTEINS DURING IMMUNIZATION : THE CAUSE OF HYPOALBUMINEMIA WITH HIGH GAMMA GLOBULIN VALUES

INVESTIGATIONS CONCERNING THE CHANGES IN SERUM PROTEINS DURING IMMUNIZATION : THE CAUSE OF HYPOALBUMINEMIA WITH HIGH GAMMA GLOBULIN VALUES

On hyperimmunization of rabbits with pneumococcal vaccine, increase in the content of gamma globulin and fall of albumin in the serum are produced. In such hyperimmunized rabbits, investigations of the plasma volume, albumin degradation, and the distribution of the albumin intra- and extravascularl...

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Main Authors: Bjørneboe, M., Schwartz, Michael
Format: Online
Language:English
Published: The Rockefeller University Press 1959
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136995/
id pubmed-2136995
recordtype oai_dc
spelling pubmed-21369952008-04-17 INVESTIGATIONS CONCERNING THE CHANGES IN SERUM PROTEINS DURING IMMUNIZATION : THE CAUSE OF HYPOALBUMINEMIA WITH HIGH GAMMA GLOBULIN VALUES Bjørneboe, M. Schwartz, Michael Article On hyperimmunization of rabbits with pneumococcal vaccine, increase in the content of gamma globulin and fall of albumin in the serum are produced. In such hyperimmunized rabbits, investigations of the plasma volume, albumin degradation, and the distribution of the albumin intra- and extravascularly were undertaken by Sterling's method employing rabbit albumin labelled with I131. The investigations do not suggest any significant alteration in the albumin degradation nor in the distribution between the intra- and extravascular albumin. It was demonstrated that the plasma volume increases simultaneously with increase in the gamma globulin and fall in albumin. It is concluded that the fall in serum albumin observed is due to a regulative mechanism which attempts to maintain the colloid-osmotic pressure by increasing the plasma volume. The Rockefeller University Press 1959-08-01 /pmc/articles/PMC2136995/ /pubmed/13673138 Text en Copyright © Copyright, 1959, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Bjørneboe, M.
Schwartz, Michael
spellingShingle Bjørneboe, M.
Schwartz, Michael
INVESTIGATIONS CONCERNING THE CHANGES IN SERUM PROTEINS DURING IMMUNIZATION : THE CAUSE OF HYPOALBUMINEMIA WITH HIGH GAMMA GLOBULIN VALUES
author_facet Bjørneboe, M.
Schwartz, Michael
author_sort Bjørneboe, M.
title INVESTIGATIONS CONCERNING THE CHANGES IN SERUM PROTEINS DURING IMMUNIZATION : THE CAUSE OF HYPOALBUMINEMIA WITH HIGH GAMMA GLOBULIN VALUES
title_short INVESTIGATIONS CONCERNING THE CHANGES IN SERUM PROTEINS DURING IMMUNIZATION : THE CAUSE OF HYPOALBUMINEMIA WITH HIGH GAMMA GLOBULIN VALUES
title_full INVESTIGATIONS CONCERNING THE CHANGES IN SERUM PROTEINS DURING IMMUNIZATION : THE CAUSE OF HYPOALBUMINEMIA WITH HIGH GAMMA GLOBULIN VALUES
title_fullStr INVESTIGATIONS CONCERNING THE CHANGES IN SERUM PROTEINS DURING IMMUNIZATION : THE CAUSE OF HYPOALBUMINEMIA WITH HIGH GAMMA GLOBULIN VALUES
title_full_unstemmed INVESTIGATIONS CONCERNING THE CHANGES IN SERUM PROTEINS DURING IMMUNIZATION : THE CAUSE OF HYPOALBUMINEMIA WITH HIGH GAMMA GLOBULIN VALUES
title_sort investigations concerning the changes in serum proteins during immunization : the cause of hypoalbuminemia with high gamma globulin values
description On hyperimmunization of rabbits with pneumococcal vaccine, increase in the content of gamma globulin and fall of albumin in the serum are produced. In such hyperimmunized rabbits, investigations of the plasma volume, albumin degradation, and the distribution of the albumin intra- and extravascularly were undertaken by Sterling's method employing rabbit albumin labelled with I131. The investigations do not suggest any significant alteration in the albumin degradation nor in the distribution between the intra- and extravascular albumin. It was demonstrated that the plasma volume increases simultaneously with increase in the gamma globulin and fall in albumin. It is concluded that the fall in serum albumin observed is due to a regulative mechanism which attempts to maintain the colloid-osmotic pressure by increasing the plasma volume.
publisher The Rockefeller University Press
publishDate 1959
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136995/
_version_ 1611420358988005376

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