BLOOD PRESSURE, CHOLESTEROL CONTENT OF SERUM AND TISSUES, AND ATHEROGENESIS IN THE RAT : THE EFFECT OF VARIATIONS IN BLOOD PRESSURE ON THE CHOLESTEROL CONTENT OF SERUM AND TISSUES AND ON THE DEVELOPMENT OF ATHEROSCLEROSIS IN RATS ON A HIGH CHOLESTEROL DIET

Rats on a stock diet with added cholesterol, cholic acid, and thiouracil developed increased concentrations of cholesterol, total lipide, and beta lipoprotein in the serum, and an increased content of cholesterol in the liver and carcass, despite the fact that the diet produced a cessation of endog...

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Main Authors:	Deming, Q. B., Mosbach, E. H., Bevans, M., Daly, M. M., Abell, L. L., Martin, E., Brun, L. M., Halpern, E., Kaplan, R.
Format:	Online
Language:	English
Published:	The Rockefeller University Press 1958
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136835/

id	pubmed-2136835
recordtype	oai_dc
spelling	pubmed-21368352008-04-17 BLOOD PRESSURE, CHOLESTEROL CONTENT OF SERUM AND TISSUES, AND ATHEROGENESIS IN THE RAT : THE EFFECT OF VARIATIONS IN BLOOD PRESSURE ON THE CHOLESTEROL CONTENT OF SERUM AND TISSUES AND ON THE DEVELOPMENT OF ATHEROSCLEROSIS IN RATS ON A HIGH CHOLESTEROL DIET Deming, Q. B. Mosbach, E. H. Bevans, M. Daly, M. M. Abell, L. L. Martin, E. Brun, L. M. Halpern, E. Kaplan, R. Article Rats on a stock diet with added cholesterol, cholic acid, and thiouracil developed increased concentrations of cholesterol, total lipide, and beta lipoprotein in the serum, and an increased content of cholesterol in the liver and carcass, despite the fact that the diet produced a cessation of endogenous cholesterol synthesis. Rats with high serum lipide concentrations developed intimal lesions similar to those of human atherosclerosis. The induction of hypertension by desoxycorticosterone and salt accelerated the development of hypercholesterolemia, hyperlipemia, increase in tissue cholesterol content, and atherosclerotic changes in the intima. Hypertension induced by renal artery constriction also intensified the hypercholesterolemia and hyperlipemia. On the other hand, rats receiving desoxycorticosterone acetate without salt or salt without desoxycorticosterone acetate did not show any intensification of hypercholesterolemia or hyperlipemia. The extent of the atherosclerotic lesions was correlated with the concentration of cholesterol in the serum. There was also a positive correlation between blood pressure and the degree of hypercholesterolemia. It remained uncertain whether the increase in atherosclerosis in the hypertensive animals was dependent on the increased lipide content of serum and tissues or on a local effect of the elevated blood pressure. The Rockefeller University Press 1958-03-31 /pmc/articles/PMC2136835/ /pubmed/13513919 Text en Copyright © Copyright, 1958, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Deming, Q. B. Mosbach, E. H. Bevans, M. Daly, M. M. Abell, L. L. Martin, E. Brun, L. M. Halpern, E. Kaplan, R.
spellingShingle	Deming, Q. B. Mosbach, E. H. Bevans, M. Daly, M. M. Abell, L. L. Martin, E. Brun, L. M. Halpern, E. Kaplan, R. BLOOD PRESSURE, CHOLESTEROL CONTENT OF SERUM AND TISSUES, AND ATHEROGENESIS IN THE RAT : THE EFFECT OF VARIATIONS IN BLOOD PRESSURE ON THE CHOLESTEROL CONTENT OF SERUM AND TISSUES AND ON THE DEVELOPMENT OF ATHEROSCLEROSIS IN RATS ON A HIGH CHOLESTEROL DIET
author_facet	Deming, Q. B. Mosbach, E. H. Bevans, M. Daly, M. M. Abell, L. L. Martin, E. Brun, L. M. Halpern, E. Kaplan, R.
author_sort	Deming, Q. B.
title	BLOOD PRESSURE, CHOLESTEROL CONTENT OF SERUM AND TISSUES, AND ATHEROGENESIS IN THE RAT : THE EFFECT OF VARIATIONS IN BLOOD PRESSURE ON THE CHOLESTEROL CONTENT OF SERUM AND TISSUES AND ON THE DEVELOPMENT OF ATHEROSCLEROSIS IN RATS ON A HIGH CHOLESTEROL DIET
title_short	BLOOD PRESSURE, CHOLESTEROL CONTENT OF SERUM AND TISSUES, AND ATHEROGENESIS IN THE RAT : THE EFFECT OF VARIATIONS IN BLOOD PRESSURE ON THE CHOLESTEROL CONTENT OF SERUM AND TISSUES AND ON THE DEVELOPMENT OF ATHEROSCLEROSIS IN RATS ON A HIGH CHOLESTEROL DIET
title_full	BLOOD PRESSURE, CHOLESTEROL CONTENT OF SERUM AND TISSUES, AND ATHEROGENESIS IN THE RAT : THE EFFECT OF VARIATIONS IN BLOOD PRESSURE ON THE CHOLESTEROL CONTENT OF SERUM AND TISSUES AND ON THE DEVELOPMENT OF ATHEROSCLEROSIS IN RATS ON A HIGH CHOLESTEROL DIET
title_fullStr	BLOOD PRESSURE, CHOLESTEROL CONTENT OF SERUM AND TISSUES, AND ATHEROGENESIS IN THE RAT : THE EFFECT OF VARIATIONS IN BLOOD PRESSURE ON THE CHOLESTEROL CONTENT OF SERUM AND TISSUES AND ON THE DEVELOPMENT OF ATHEROSCLEROSIS IN RATS ON A HIGH CHOLESTEROL DIET
title_full_unstemmed	BLOOD PRESSURE, CHOLESTEROL CONTENT OF SERUM AND TISSUES, AND ATHEROGENESIS IN THE RAT : THE EFFECT OF VARIATIONS IN BLOOD PRESSURE ON THE CHOLESTEROL CONTENT OF SERUM AND TISSUES AND ON THE DEVELOPMENT OF ATHEROSCLEROSIS IN RATS ON A HIGH CHOLESTEROL DIET
title_sort	blood pressure, cholesterol content of serum and tissues, and atherogenesis in the rat : the effect of variations in blood pressure on the cholesterol content of serum and tissues and on the development of atherosclerosis in rats on a high cholesterol diet
description	Rats on a stock diet with added cholesterol, cholic acid, and thiouracil developed increased concentrations of cholesterol, total lipide, and beta lipoprotein in the serum, and an increased content of cholesterol in the liver and carcass, despite the fact that the diet produced a cessation of endogenous cholesterol synthesis. Rats with high serum lipide concentrations developed intimal lesions similar to those of human atherosclerosis. The induction of hypertension by desoxycorticosterone and salt accelerated the development of hypercholesterolemia, hyperlipemia, increase in tissue cholesterol content, and atherosclerotic changes in the intima. Hypertension induced by renal artery constriction also intensified the hypercholesterolemia and hyperlipemia. On the other hand, rats receiving desoxycorticosterone acetate without salt or salt without desoxycorticosterone acetate did not show any intensification of hypercholesterolemia or hyperlipemia. The extent of the atherosclerotic lesions was correlated with the concentration of cholesterol in the serum. There was also a positive correlation between blood pressure and the degree of hypercholesterolemia. It remained uncertain whether the increase in atherosclerosis in the hypertensive animals was dependent on the increased lipide content of serum and tissues or on a local effect of the elevated blood pressure.
publisher	The Rockefeller University Press
publishDate	1958
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136835/
_version_	1611420266156523520

BLOOD PRESSURE, CHOLESTEROL CONTENT OF SERUM AND TISSUES, AND ATHEROGENESIS IN THE RAT : THE EFFECT OF VARIATIONS IN BLOOD PRESSURE ON THE CHOLESTEROL CONTENT OF SERUM AND TISSUES AND ON THE DEVELOPMENT OF ATHEROSCLEROSIS IN RATS ON A HIGH CHOLESTEROL DIET

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