INTERRELATIONSHIPS BETWEEN EXPERIMENTAL HYPERCHOLESTEREMIA, MAGNESIUM REQUIREMENT, AND EXPERIMENTAL ATHEROSCLEROSIS

The addition of cholesterol and cholic acid to a diet containing 24 mg. percent of magnesium, an amount normally required for young rats, resulted in magnesium deficiency in rats. This was characterized by hyperexcitability, hyperemia of the ears, calcium deposition in the kidney tubules, low serum...

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Main Authors:	Vitale, J. J., White, P. L., Nakamura, M., Hegsted, D. M., Zamcheck, N., Hellerstein, E. E.
Format:	Online
Language:	English
Published:	The Rockefeller University Press 1957
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136817/

id	pubmed-2136817
recordtype	oai_dc
spelling	pubmed-21368172008-04-17 INTERRELATIONSHIPS BETWEEN EXPERIMENTAL HYPERCHOLESTEREMIA, MAGNESIUM REQUIREMENT, AND EXPERIMENTAL ATHEROSCLEROSIS Vitale, J. J. White, P. L. Nakamura, M. Hegsted, D. M. Zamcheck, N. Hellerstein, E. E. Article The addition of cholesterol and cholic acid to a diet containing 24 mg. percent of magnesium, an amount normally required for young rats, resulted in magnesium deficiency in rats. This was characterized by hyperexcitability, hyperemia of the ears, calcium deposition in the kidney tubules, low serum magnesium levels, and decreased oxidative phosphorylation of heart mitochondria. All these lesions were prevented by raising the dietary magnesium level four to eight times. Feeding the atherogenic diet produced the deposition of lipide in the aorta and in the heart valves. The extent of this intimal sudanophilia was reduced by large amounts of dietary magnesium although serum cholesterol values did not fall and usually rose. This represents perhaps the first clear cut disassociation between serum cholesterol values and the extent of intimal sudanophilia. Raising the level of dietary protein from 10 to 20 per cent decreased the serum cholesterol levels and the extent of the kidney lesions. Thyroxine administration lowered the serum cholesterol values, abolished the kidney lesions and reduced the intimal sudanophilia. These effects occurred even though the serum magnesium levels remained low. The Rockefeller University Press 1957-10-31 /pmc/articles/PMC2136817/ /pubmed/13475629 Text en Copyright © Copyright, 1957, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Vitale, J. J. White, P. L. Nakamura, M. Hegsted, D. M. Zamcheck, N. Hellerstein, E. E.
spellingShingle	Vitale, J. J. White, P. L. Nakamura, M. Hegsted, D. M. Zamcheck, N. Hellerstein, E. E. INTERRELATIONSHIPS BETWEEN EXPERIMENTAL HYPERCHOLESTEREMIA, MAGNESIUM REQUIREMENT, AND EXPERIMENTAL ATHEROSCLEROSIS
author_facet	Vitale, J. J. White, P. L. Nakamura, M. Hegsted, D. M. Zamcheck, N. Hellerstein, E. E.
author_sort	Vitale, J. J.
title	INTERRELATIONSHIPS BETWEEN EXPERIMENTAL HYPERCHOLESTEREMIA, MAGNESIUM REQUIREMENT, AND EXPERIMENTAL ATHEROSCLEROSIS
title_short	INTERRELATIONSHIPS BETWEEN EXPERIMENTAL HYPERCHOLESTEREMIA, MAGNESIUM REQUIREMENT, AND EXPERIMENTAL ATHEROSCLEROSIS
title_full	INTERRELATIONSHIPS BETWEEN EXPERIMENTAL HYPERCHOLESTEREMIA, MAGNESIUM REQUIREMENT, AND EXPERIMENTAL ATHEROSCLEROSIS
title_fullStr	INTERRELATIONSHIPS BETWEEN EXPERIMENTAL HYPERCHOLESTEREMIA, MAGNESIUM REQUIREMENT, AND EXPERIMENTAL ATHEROSCLEROSIS
title_full_unstemmed	INTERRELATIONSHIPS BETWEEN EXPERIMENTAL HYPERCHOLESTEREMIA, MAGNESIUM REQUIREMENT, AND EXPERIMENTAL ATHEROSCLEROSIS
title_sort	interrelationships between experimental hypercholesteremia, magnesium requirement, and experimental atherosclerosis
description	The addition of cholesterol and cholic acid to a diet containing 24 mg. percent of magnesium, an amount normally required for young rats, resulted in magnesium deficiency in rats. This was characterized by hyperexcitability, hyperemia of the ears, calcium deposition in the kidney tubules, low serum magnesium levels, and decreased oxidative phosphorylation of heart mitochondria. All these lesions were prevented by raising the dietary magnesium level four to eight times. Feeding the atherogenic diet produced the deposition of lipide in the aorta and in the heart valves. The extent of this intimal sudanophilia was reduced by large amounts of dietary magnesium although serum cholesterol values did not fall and usually rose. This represents perhaps the first clear cut disassociation between serum cholesterol values and the extent of intimal sudanophilia. Raising the level of dietary protein from 10 to 20 per cent decreased the serum cholesterol levels and the extent of the kidney lesions. Thyroxine administration lowered the serum cholesterol values, abolished the kidney lesions and reduced the intimal sudanophilia. These effects occurred even though the serum magnesium levels remained low.
publisher	The Rockefeller University Press
publishDate	1957
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136817/
_version_	1611420255424348160

INTERRELATIONSHIPS BETWEEN EXPERIMENTAL HYPERCHOLESTEREMIA, MAGNESIUM REQUIREMENT, AND EXPERIMENTAL ATHEROSCLEROSIS

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