ANALYTICAL PATHOLOGY : IV. THE ROLE OF LOCALIZED ANTIBODIES IN THE PATHOGENESIS OF NEPHROTOXIC NEPHRITIS IN THE RAT

ANALYTICAL PATHOLOGY : IV. THE ROLE OF LOCALIZED ANTIBODIES IN THE PATHOGENESIS OF NEPHROTOXIC NEPHRITIS IN THE RAT

The principal objective of this investigation was to define the roles of injected and autogenous, kidney-localizing antibodies in the pathogenesis of rat nephrotoxic nephritis by relating data obtained with fluorescent antibody techniques to clinical and histologic observations. Such an analysis of...

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Main Authors: Ortega, Louis G., Mellors, Robert C.
Format: Online
Language:English
Published: The Rockefeller University Press 1956
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136635/
id pubmed-2136635
recordtype oai_dc
spelling pubmed-21366352008-04-17 ANALYTICAL PATHOLOGY : IV. THE ROLE OF LOCALIZED ANTIBODIES IN THE PATHOGENESIS OF NEPHROTOXIC NEPHRITIS IN THE RAT Ortega, Louis G. Mellors, Robert C. Article The principal objective of this investigation was to define the roles of injected and autogenous, kidney-localizing antibodies in the pathogenesis of rat nephrotoxic nephritis by relating data obtained with fluorescent antibody techniques to clinical and histologic observations. Such an analysis of the nephritis that developed in 28 rats after injection with the crude γ-globulin fraction of nephrotoxic serum has led us to the following conclusions:— The renal localization of nephrotoxic antibodies is primarily and, perhaps, exclusively in the membranes of the glomerular tufts. These antibodies are demonstrable, as antigens, in the glomeruli for up to 3 months after injection. In the acute stage of the nephritis, non-antibody, autogenous globulins are present in the glomerular tufts, probably as components of edema fluid. From 6 and 9 days to 3 months after injection, autogenous antibodies are localized in the glomerular tufts in a pattern that corresponds closely to that of the nephrotoxins. The essential requirements for the operation of the mechanism postulated by Kay are fulfilled in rat nephrotoxic nephritis. The Rockefeller University Press 1956-07-01 /pmc/articles/PMC2136635/ /pubmed/13332186 Text en Copyright © Copyright, 1956, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Ortega, Louis G.
Mellors, Robert C.
spellingShingle Ortega, Louis G.
Mellors, Robert C.
ANALYTICAL PATHOLOGY : IV. THE ROLE OF LOCALIZED ANTIBODIES IN THE PATHOGENESIS OF NEPHROTOXIC NEPHRITIS IN THE RAT
author_facet Ortega, Louis G.
Mellors, Robert C.
author_sort Ortega, Louis G.
title ANALYTICAL PATHOLOGY : IV. THE ROLE OF LOCALIZED ANTIBODIES IN THE PATHOGENESIS OF NEPHROTOXIC NEPHRITIS IN THE RAT
title_short ANALYTICAL PATHOLOGY : IV. THE ROLE OF LOCALIZED ANTIBODIES IN THE PATHOGENESIS OF NEPHROTOXIC NEPHRITIS IN THE RAT
title_full ANALYTICAL PATHOLOGY : IV. THE ROLE OF LOCALIZED ANTIBODIES IN THE PATHOGENESIS OF NEPHROTOXIC NEPHRITIS IN THE RAT
title_fullStr ANALYTICAL PATHOLOGY : IV. THE ROLE OF LOCALIZED ANTIBODIES IN THE PATHOGENESIS OF NEPHROTOXIC NEPHRITIS IN THE RAT
title_full_unstemmed ANALYTICAL PATHOLOGY : IV. THE ROLE OF LOCALIZED ANTIBODIES IN THE PATHOGENESIS OF NEPHROTOXIC NEPHRITIS IN THE RAT
title_sort analytical pathology : iv. the role of localized antibodies in the pathogenesis of nephrotoxic nephritis in the rat
description The principal objective of this investigation was to define the roles of injected and autogenous, kidney-localizing antibodies in the pathogenesis of rat nephrotoxic nephritis by relating data obtained with fluorescent antibody techniques to clinical and histologic observations. Such an analysis of the nephritis that developed in 28 rats after injection with the crude γ-globulin fraction of nephrotoxic serum has led us to the following conclusions:— The renal localization of nephrotoxic antibodies is primarily and, perhaps, exclusively in the membranes of the glomerular tufts. These antibodies are demonstrable, as antigens, in the glomeruli for up to 3 months after injection. In the acute stage of the nephritis, non-antibody, autogenous globulins are present in the glomerular tufts, probably as components of edema fluid. From 6 and 9 days to 3 months after injection, autogenous antibodies are localized in the glomerular tufts in a pattern that corresponds closely to that of the nephrotoxins. The essential requirements for the operation of the mechanism postulated by Kay are fulfilled in rat nephrotoxic nephritis.
publisher The Rockefeller University Press
publishDate 1956
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136635/
_version_ 1611420148092108800

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