Protein Kinase C Activation Upregulates Intercellular Adhesion of α-Catenin–negative Human Colon Cancer Cell Variants via Induction of Desmosomes

Protein Kinase C Activation Upregulates Intercellular Adhesion of α-Catenin–negative Human Colon Cancer Cell Variants via Induction of Desmosomes

The α-catenin molecule links E-cadherin/ β-catenin or E-cadherin/plakoglobin complexes to the actin cytoskeleton. We studied several invasive human colon carcinoma cell lines lacking α-catenin. They showed a solitary and rounded morphotype that correlated with increased invasiveness. These round cel...

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Bibliographic Details
Main Authors: van Hengel, Jolanda, Gohon, Lionel, Bruyneel, Erik, Vermeulen, Stefan, Cornelissen, Maria, Mareel, Marc, van Roy, Frans
Format: Online
Language:English
Published: The Rockefeller University Press 1997
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136213/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136213/

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