THE BEHAVIOR OF POX VIRUSES IN THE RESPIRATORY TRACT : IV. THE NASAL INSTILLATION OF FOWL POX VIRUS IN CHICKENS AND IN MICE

Fowl pox virus from active skin lesions was established in the upper respiratory tract of normal chickens by nasal instillation and maintained for 12 successive passages. The nasal infection was not communicable by direct contact but did afford protection, for at least 6 weeks, against subsequent d...

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Main Author:	Nelson, John B.
Format:	Online
Language:	English
Published:	The Rockefeller University Press 1941
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135176/

id	pubmed-2135176
recordtype	oai_dc
spelling	pubmed-21351762008-04-18 THE BEHAVIOR OF POX VIRUSES IN THE RESPIRATORY TRACT : IV. THE NASAL INSTILLATION OF FOWL POX VIRUS IN CHICKENS AND IN MICE Nelson, John B. Article Fowl pox virus from active skin lesions was established in the upper respiratory tract of normal chickens by nasal instillation and maintained for 12 successive passages. The nasal infection was not communicable by direct contact but did afford protection, for at least 6 weeks, against subsequent development of the virus in the skin. Multiplication of the virus in the nasal passages was only irregularly attended by specific mucosal changes and was not accompanied by the vigorous counter-reaction engendered by the causal agents of roup. The same strain of virus on propagation in embryonated eggs also survived and multiplied in the nasal tract but with somewhat reduced activity, the 34th egg transfer failing to afford complete protection. Nasal instillation in mice was followed only by a reaction in the lung from which the virus was recoverable through the 7th day. The Rockefeller University Press 1941-08-31 /pmc/articles/PMC2135176/ /pubmed/19871128 Text en Copyright © Copyright, 1941, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Nelson, John B.
spellingShingle	Nelson, John B. THE BEHAVIOR OF POX VIRUSES IN THE RESPIRATORY TRACT : IV. THE NASAL INSTILLATION OF FOWL POX VIRUS IN CHICKENS AND IN MICE
author_facet	Nelson, John B.
author_sort	Nelson, John B.
title	THE BEHAVIOR OF POX VIRUSES IN THE RESPIRATORY TRACT : IV. THE NASAL INSTILLATION OF FOWL POX VIRUS IN CHICKENS AND IN MICE
title_short	THE BEHAVIOR OF POX VIRUSES IN THE RESPIRATORY TRACT : IV. THE NASAL INSTILLATION OF FOWL POX VIRUS IN CHICKENS AND IN MICE
title_full	THE BEHAVIOR OF POX VIRUSES IN THE RESPIRATORY TRACT : IV. THE NASAL INSTILLATION OF FOWL POX VIRUS IN CHICKENS AND IN MICE
title_fullStr	THE BEHAVIOR OF POX VIRUSES IN THE RESPIRATORY TRACT : IV. THE NASAL INSTILLATION OF FOWL POX VIRUS IN CHICKENS AND IN MICE
title_full_unstemmed	THE BEHAVIOR OF POX VIRUSES IN THE RESPIRATORY TRACT : IV. THE NASAL INSTILLATION OF FOWL POX VIRUS IN CHICKENS AND IN MICE
title_sort	behavior of pox viruses in the respiratory tract : iv. the nasal instillation of fowl pox virus in chickens and in mice
description	Fowl pox virus from active skin lesions was established in the upper respiratory tract of normal chickens by nasal instillation and maintained for 12 successive passages. The nasal infection was not communicable by direct contact but did afford protection, for at least 6 weeks, against subsequent development of the virus in the skin. Multiplication of the virus in the nasal passages was only irregularly attended by specific mucosal changes and was not accompanied by the vigorous counter-reaction engendered by the causal agents of roup. The same strain of virus on propagation in embryonated eggs also survived and multiplied in the nasal tract but with somewhat reduced activity, the 34th egg transfer failing to afford complete protection. Nasal instillation in mice was followed only by a reaction in the lung from which the virus was recoverable through the 7th day.
publisher	The Rockefeller University Press
publishDate	1941
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135176/
_version_	1611419316553515008

THE BEHAVIOR OF POX VIRUSES IN THE RESPIRATORY TRACT : IV. THE NASAL INSTILLATION OF FOWL POX VIRUS IN CHICKENS AND IN MICE

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