STUDIES IN THE BLOOD CYTOLOGY OF THE RABBIT : VII. OBSERVATIONS ON RABBITS INOCULATED WITH A TRANSPLANTABLE MALIGNANT NEOPLASM

STUDIES IN THE BLOOD CYTOLOGY OF THE RABBIT : VII. OBSERVATIONS ON RABBITS INOCULATED WITH A TRANSPLANTABLE MALIGNANT NEOPLASM

Successive blood counts at weekly intervals were made on rabbits inoculated with a transplantable malignant neoplasm of epithelial origin. There were 78 animals distributed in 9 groups; the period of observation after inoculation was 2 months. The results have been considered with respect to the ch...

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Main Authors: Pearce, Louise, Casey, Albert E.
Format: Online
Language:English
Published: The Rockefeller University Press 1931
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132032/
id pubmed-2132032
recordtype oai_dc
spelling pubmed-21320322008-04-18 STUDIES IN THE BLOOD CYTOLOGY OF THE RABBIT : VII. OBSERVATIONS ON RABBITS INOCULATED WITH A TRANSPLANTABLE MALIGNANT NEOPLASM Pearce, Louise Casey, Albert E. Article Successive blood counts at weekly intervals were made on rabbits inoculated with a transplantable malignant neoplasm of epithelial origin. There were 78 animals distributed in 9 groups; the period of observation after inoculation was 2 months. The results have been considered with respect to the character of the tumor process as determined by postmortem examination, the animals being classified as deaths, probable deaths, probable recoveries, and recoveries. The blood findings have been analyzed on the basis of the values derived from normal rabbits. A comparison has also been made with the results of preinoculation counts. In rabbits in which the tumor process was of pronounced or well marked severity, the numbers of monocytes became greatly increased; the neutrophiles and the total white blood cells were also increased; the eosinophiles, and to a less extent, the basophiles and lymphocytes were decreased; the red cell count was decreased and the hemoglobin content was lowered. In rabbits which recovered from the tumor inoculation, there were no outstanding changes in the blood picture when the findings for the entire observation period were considered. In the group of probable recoveries, the results were variable; there was, however, a definite although moderate increase of monocytes, and in general, the findings reflected the mildness of the disease when compared with those of the fatal cases and the group of probable deaths. The Rockefeller University Press 1931-05-31 /pmc/articles/PMC2132032/ /pubmed/19869892 Text en Copyright © Copyright, 1931, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Pearce, Louise
Casey, Albert E.
spellingShingle Pearce, Louise
Casey, Albert E.
STUDIES IN THE BLOOD CYTOLOGY OF THE RABBIT : VII. OBSERVATIONS ON RABBITS INOCULATED WITH A TRANSPLANTABLE MALIGNANT NEOPLASM
author_facet Pearce, Louise
Casey, Albert E.
author_sort Pearce, Louise
title STUDIES IN THE BLOOD CYTOLOGY OF THE RABBIT : VII. OBSERVATIONS ON RABBITS INOCULATED WITH A TRANSPLANTABLE MALIGNANT NEOPLASM
title_short STUDIES IN THE BLOOD CYTOLOGY OF THE RABBIT : VII. OBSERVATIONS ON RABBITS INOCULATED WITH A TRANSPLANTABLE MALIGNANT NEOPLASM
title_full STUDIES IN THE BLOOD CYTOLOGY OF THE RABBIT : VII. OBSERVATIONS ON RABBITS INOCULATED WITH A TRANSPLANTABLE MALIGNANT NEOPLASM
title_fullStr STUDIES IN THE BLOOD CYTOLOGY OF THE RABBIT : VII. OBSERVATIONS ON RABBITS INOCULATED WITH A TRANSPLANTABLE MALIGNANT NEOPLASM
title_full_unstemmed STUDIES IN THE BLOOD CYTOLOGY OF THE RABBIT : VII. OBSERVATIONS ON RABBITS INOCULATED WITH A TRANSPLANTABLE MALIGNANT NEOPLASM
title_sort studies in the blood cytology of the rabbit : vii. observations on rabbits inoculated with a transplantable malignant neoplasm
description Successive blood counts at weekly intervals were made on rabbits inoculated with a transplantable malignant neoplasm of epithelial origin. There were 78 animals distributed in 9 groups; the period of observation after inoculation was 2 months. The results have been considered with respect to the character of the tumor process as determined by postmortem examination, the animals being classified as deaths, probable deaths, probable recoveries, and recoveries. The blood findings have been analyzed on the basis of the values derived from normal rabbits. A comparison has also been made with the results of preinoculation counts. In rabbits in which the tumor process was of pronounced or well marked severity, the numbers of monocytes became greatly increased; the neutrophiles and the total white blood cells were also increased; the eosinophiles, and to a less extent, the basophiles and lymphocytes were decreased; the red cell count was decreased and the hemoglobin content was lowered. In rabbits which recovered from the tumor inoculation, there were no outstanding changes in the blood picture when the findings for the entire observation period were considered. In the group of probable recoveries, the results were variable; there was, however, a definite although moderate increase of monocytes, and in general, the findings reflected the mildness of the disease when compared with those of the fatal cases and the group of probable deaths.
publisher The Rockefeller University Press
publishDate 1931
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132032/
_version_ 1611418105967280128

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