ATTEMPTS TO TRANSMIT RHEUMATIC FEVER TO RABBITS AND GUINEA PIGS

ATTEMPTS TO TRANSMIT RHEUMATIC FEVER TO RABBITS AND GUINEA PIGS

In a series of attempts to transmit a virus from patients in the acute stages of rheumatic fever, twenty-seven rabbits and fourteen guinea pigs were inoculated with one of the following materials: whole blood, serum, joint fluid, pleural fluid, throat washings, suspensions of tonsil tissue. Subsequ...

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Main Author: Miller, C. Philip
Format: Online
Language:English
Published: The Rockefeller University Press 1924
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128582/
id pubmed-2128582
recordtype oai_dc
spelling pubmed-21285822008-04-18 ATTEMPTS TO TRANSMIT RHEUMATIC FEVER TO RABBITS AND GUINEA PIGS Miller, C. Philip Article In a series of attempts to transmit a virus from patients in the acute stages of rheumatic fever, twenty-seven rabbits and fourteen guinea pigs were inoculated with one of the following materials: whole blood, serum, joint fluid, pleural fluid, throat washings, suspensions of tonsil tissue. Subsequent transfer inoculations from animal to animal brought the total number of animals employed in the experiments to 67 rabbits and 40 guinea pigs. Only two animals developed an acute non-bacterial arthritis. No other evidence of successful transmission of the disease was obtained. In about one-half of the rabbits and two-thirds of the guinea pigs myocardial lesions were encountered which consisted of interstitial accumulations of lymphocytes and endothelial cells. Similar lesions were found in control animals. The Rockefeller University Press 1924-09-30 /pmc/articles/PMC2128582/ /pubmed/19868938 Text en Copyright © Copyright, 1924, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Miller, C. Philip
spellingShingle Miller, C. Philip
ATTEMPTS TO TRANSMIT RHEUMATIC FEVER TO RABBITS AND GUINEA PIGS
author_facet Miller, C. Philip
author_sort Miller, C. Philip
title ATTEMPTS TO TRANSMIT RHEUMATIC FEVER TO RABBITS AND GUINEA PIGS
title_short ATTEMPTS TO TRANSMIT RHEUMATIC FEVER TO RABBITS AND GUINEA PIGS
title_full ATTEMPTS TO TRANSMIT RHEUMATIC FEVER TO RABBITS AND GUINEA PIGS
title_fullStr ATTEMPTS TO TRANSMIT RHEUMATIC FEVER TO RABBITS AND GUINEA PIGS
title_full_unstemmed ATTEMPTS TO TRANSMIT RHEUMATIC FEVER TO RABBITS AND GUINEA PIGS
title_sort attempts to transmit rheumatic fever to rabbits and guinea pigs
description In a series of attempts to transmit a virus from patients in the acute stages of rheumatic fever, twenty-seven rabbits and fourteen guinea pigs were inoculated with one of the following materials: whole blood, serum, joint fluid, pleural fluid, throat washings, suspensions of tonsil tissue. Subsequent transfer inoculations from animal to animal brought the total number of animals employed in the experiments to 67 rabbits and 40 guinea pigs. Only two animals developed an acute non-bacterial arthritis. No other evidence of successful transmission of the disease was obtained. In about one-half of the rabbits and two-thirds of the guinea pigs myocardial lesions were encountered which consisted of interstitial accumulations of lymphocytes and endothelial cells. Similar lesions were found in control animals.
publisher The Rockefeller University Press
publishDate 1924
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128582/
_version_ 1611417470704287744

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