STUDIES ON CALCIUM AND MAGNESIUM METABOLISM IN DISEASE : II. CALCIUM AND MAGNESIUM METABOLISM IN MULTIPLE CARTILAGINOUS EXOSTOSIS.

In the stabilized stage of exostosis calcium exchange differs little from that of a normal individual whether the abnormal subject is maintained upon a calcium-poor diet or upon one rich in this element. In the progressive stage of the disease calcium metabolism is markedly different from the norma...

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Main Authors:	Underhill, Frank P., Honeij, James A., Bogert, L. Jean
Format:	Online
Language:	English
Published:	The Rockefeller University Press 1920
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128261/

id	pubmed-2128261
recordtype	oai_dc
spelling	pubmed-21282612008-04-18 STUDIES ON CALCIUM AND MAGNESIUM METABOLISM IN DISEASE : II. CALCIUM AND MAGNESIUM METABOLISM IN MULTIPLE CARTILAGINOUS EXOSTOSIS. Underhill, Frank P. Honeij, James A. Bogert, L. Jean Article In the stabilized stage of exostosis calcium exchange differs little from that of a normal individual whether the abnormal subject is maintained upon a calcium-poor diet or upon one rich in this element. In the progressive stage of the disease calcium metabolism is markedly different from the normal in that calcium is lost from the body in large amounts when the subject is maintained upon a calcium-poor diet. This excessive elimination of calcium is by way of both the urine and feces in a normal ratio. When placed upon a calcium-rich diet calcium is retained to an extent not widely deviating from that obtained in normal subjects. A resumption to a calcium-poor diet again induces excessive calcium elimination. In the stabilized stage of exostosis magnesium excretion is two or three times greater than the intake whether the subject is maintained upon a diet poor or rich in magnesium. In the progressive stage of the disease the general type of magnesium excretion resembles that of the stabilized stage but the degree of elimination is not so marked. Magnesium added to the diet in the stabilized stage is promptly excreted. The same test applied to the progressive stage gives evidence of retention of some magnesium. The degree of retention, however, is much less than that shown by normal individuals. Absorption of both calcium and magnesium in exostosis is not inferior to that of normal subjects. The facts enumerated suggest that in the early stages of exostosis, that is during the proliferative cartilage changes, the progress of the disease may perhaps be checked by proper dietary procedure — restriction of calcium and magnesium intake. The Rockefeller University Press 1920-06-30 /pmc/articles/PMC2128261/ /pubmed/19868431 Text en Copyright © Copyright, 1920, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Underhill, Frank P. Honeij, James A. Bogert, L. Jean
spellingShingle	Underhill, Frank P. Honeij, James A. Bogert, L. Jean STUDIES ON CALCIUM AND MAGNESIUM METABOLISM IN DISEASE : II. CALCIUM AND MAGNESIUM METABOLISM IN MULTIPLE CARTILAGINOUS EXOSTOSIS.
author_facet	Underhill, Frank P. Honeij, James A. Bogert, L. Jean
author_sort	Underhill, Frank P.
title	STUDIES ON CALCIUM AND MAGNESIUM METABOLISM IN DISEASE : II. CALCIUM AND MAGNESIUM METABOLISM IN MULTIPLE CARTILAGINOUS EXOSTOSIS.
title_short	STUDIES ON CALCIUM AND MAGNESIUM METABOLISM IN DISEASE : II. CALCIUM AND MAGNESIUM METABOLISM IN MULTIPLE CARTILAGINOUS EXOSTOSIS.
title_full	STUDIES ON CALCIUM AND MAGNESIUM METABOLISM IN DISEASE : II. CALCIUM AND MAGNESIUM METABOLISM IN MULTIPLE CARTILAGINOUS EXOSTOSIS.
title_fullStr	STUDIES ON CALCIUM AND MAGNESIUM METABOLISM IN DISEASE : II. CALCIUM AND MAGNESIUM METABOLISM IN MULTIPLE CARTILAGINOUS EXOSTOSIS.
title_full_unstemmed	STUDIES ON CALCIUM AND MAGNESIUM METABOLISM IN DISEASE : II. CALCIUM AND MAGNESIUM METABOLISM IN MULTIPLE CARTILAGINOUS EXOSTOSIS.
title_sort	studies on calcium and magnesium metabolism in disease : ii. calcium and magnesium metabolism in multiple cartilaginous exostosis.
description	In the stabilized stage of exostosis calcium exchange differs little from that of a normal individual whether the abnormal subject is maintained upon a calcium-poor diet or upon one rich in this element. In the progressive stage of the disease calcium metabolism is markedly different from the normal in that calcium is lost from the body in large amounts when the subject is maintained upon a calcium-poor diet. This excessive elimination of calcium is by way of both the urine and feces in a normal ratio. When placed upon a calcium-rich diet calcium is retained to an extent not widely deviating from that obtained in normal subjects. A resumption to a calcium-poor diet again induces excessive calcium elimination. In the stabilized stage of exostosis magnesium excretion is two or three times greater than the intake whether the subject is maintained upon a diet poor or rich in magnesium. In the progressive stage of the disease the general type of magnesium excretion resembles that of the stabilized stage but the degree of elimination is not so marked. Magnesium added to the diet in the stabilized stage is promptly excreted. The same test applied to the progressive stage gives evidence of retention of some magnesium. The degree of retention, however, is much less than that shown by normal individuals. Absorption of both calcium and magnesium in exostosis is not inferior to that of normal subjects. The facts enumerated suggest that in the early stages of exostosis, that is during the proliferative cartilage changes, the progress of the disease may perhaps be checked by proper dietary procedure — restriction of calcium and magnesium intake.
publisher	The Rockefeller University Press
publishDate	1920
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128261/
_version_	1611417283482091520

STUDIES ON CALCIUM AND MAGNESIUM METABOLISM IN DISEASE : II. CALCIUM AND MAGNESIUM METABOLISM IN MULTIPLE CARTILAGINOUS EXOSTOSIS.

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