THE RELATION OF THE SPLEEN TO BLOOD DESTRUCTION AND REGENERATION AND TO HEMOLYTIC JAUNDICE : XVI. THE INFLUENCE OF SPLENECTOMY AND OF BLOOD DISINTEGRATION UPON THE PRODUCTION OF BILE PIGMENT.

1. In four animals with a bile duct-ureter anastomosis and without disturbance due to obstruction or absorption, the total quantity of bile pigment output during a day under normal conditions varied from 0.0618 to 0.0678 gm. These figures are practically identical with those of Stadelmann (9, 10) b...

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Main Author:	Goto, Kingo
Format:	Online
Language:	English
Published:	The Rockefeller University Press 1917
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125815/

id	pubmed-2125815
recordtype	oai_dc
spelling	pubmed-21258152008-04-18 THE RELATION OF THE SPLEEN TO BLOOD DESTRUCTION AND REGENERATION AND TO HEMOLYTIC JAUNDICE : XVI. THE INFLUENCE OF SPLENECTOMY AND OF BLOOD DISINTEGRATION UPON THE PRODUCTION OF BILE PIGMENT. Goto, Kingo Article 1. In four animals with a bile duct-ureter anastomosis and without disturbance due to obstruction or absorption, the total quantity of bile pigment output during a day under normal conditions varied from 0.0618 to 0.0678 gm. These figures are practically identical with those of Stadelmann (9, 10) but lower than those given by Hooper and Whipple (7), who find that the average bile pigment excretion amounts to about 1 mg. per pound of body weight per 6 hours. 2. In all the experiments there is definite evidence of a decrease in bile pigment elimination after splenectomy. This is true not only of the elimination when no hemolytic agent is administered but also when excessive blood destruction is caused. Under the latter circumstances the amount of bile pigment is greatly increased but never reaches the high level of blood destruction before splenectomy. 3. These observations appear to show conclusively that the absence of the spleen influences the formation of bile pigment. To what extent the influence is mechanical, i.e., change in the course of the blood to the liver, and to what extent due to anemia, cannot be stated at present. The Rockefeller University Press 1917-12-01 /pmc/articles/PMC2125815/ /pubmed/19868184 Text en Copyright © Copyright, 1917, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Goto, Kingo
spellingShingle	Goto, Kingo THE RELATION OF THE SPLEEN TO BLOOD DESTRUCTION AND REGENERATION AND TO HEMOLYTIC JAUNDICE : XVI. THE INFLUENCE OF SPLENECTOMY AND OF BLOOD DISINTEGRATION UPON THE PRODUCTION OF BILE PIGMENT.
author_facet	Goto, Kingo
author_sort	Goto, Kingo
title	THE RELATION OF THE SPLEEN TO BLOOD DESTRUCTION AND REGENERATION AND TO HEMOLYTIC JAUNDICE : XVI. THE INFLUENCE OF SPLENECTOMY AND OF BLOOD DISINTEGRATION UPON THE PRODUCTION OF BILE PIGMENT.
title_short	THE RELATION OF THE SPLEEN TO BLOOD DESTRUCTION AND REGENERATION AND TO HEMOLYTIC JAUNDICE : XVI. THE INFLUENCE OF SPLENECTOMY AND OF BLOOD DISINTEGRATION UPON THE PRODUCTION OF BILE PIGMENT.
title_full	THE RELATION OF THE SPLEEN TO BLOOD DESTRUCTION AND REGENERATION AND TO HEMOLYTIC JAUNDICE : XVI. THE INFLUENCE OF SPLENECTOMY AND OF BLOOD DISINTEGRATION UPON THE PRODUCTION OF BILE PIGMENT.
title_fullStr	THE RELATION OF THE SPLEEN TO BLOOD DESTRUCTION AND REGENERATION AND TO HEMOLYTIC JAUNDICE : XVI. THE INFLUENCE OF SPLENECTOMY AND OF BLOOD DISINTEGRATION UPON THE PRODUCTION OF BILE PIGMENT.
title_full_unstemmed	THE RELATION OF THE SPLEEN TO BLOOD DESTRUCTION AND REGENERATION AND TO HEMOLYTIC JAUNDICE : XVI. THE INFLUENCE OF SPLENECTOMY AND OF BLOOD DISINTEGRATION UPON THE PRODUCTION OF BILE PIGMENT.
title_sort	relation of the spleen to blood destruction and regeneration and to hemolytic jaundice : xvi. the influence of splenectomy and of blood disintegration upon the production of bile pigment.
description	1. In four animals with a bile duct-ureter anastomosis and without disturbance due to obstruction or absorption, the total quantity of bile pigment output during a day under normal conditions varied from 0.0618 to 0.0678 gm. These figures are practically identical with those of Stadelmann (9, 10) but lower than those given by Hooper and Whipple (7), who find that the average bile pigment excretion amounts to about 1 mg. per pound of body weight per 6 hours. 2. In all the experiments there is definite evidence of a decrease in bile pigment elimination after splenectomy. This is true not only of the elimination when no hemolytic agent is administered but also when excessive blood destruction is caused. Under the latter circumstances the amount of bile pigment is greatly increased but never reaches the high level of blood destruction before splenectomy. 3. These observations appear to show conclusively that the absence of the spleen influences the formation of bile pigment. To what extent the influence is mechanical, i.e., change in the course of the blood to the liver, and to what extent due to anemia, cannot be stated at present.
publisher	The Rockefeller University Press
publishDate	1917
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125815/
_version_	1611417048271814656

THE RELATION OF THE SPLEEN TO BLOOD DESTRUCTION AND REGENERATION AND TO HEMOLYTIC JAUNDICE : XVI. THE INFLUENCE OF SPLENECTOMY AND OF BLOOD DISINTEGRATION UPON THE PRODUCTION OF BILE PIGMENT.

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