STUDIES ON TREPONEMA PALLIDUM AND SYPHILIS : II. SPIROCHÆTICIDAL ANTIBODIES AGAINST TREPONEMA PALLIDUM.

We believe that our experiments have shown that the serum of rabbits and sheep immunized with cultures of Treponema pallidum acquires spirochæticidal properties for these culture spirochætes. The normal serum of these animals also possesses spirochæticidal action if used in sufficient quantities, a...

Full description

Bibliographic Details
Main Authors:	Zinsser, Hans, Hopkins, J. G.
Format:	Online
Language:	English
Published:	The Rockefeller University Press 1916
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125427/

id	pubmed-2125427
recordtype	oai_dc
spelling	pubmed-21254272008-04-18 STUDIES ON TREPONEMA PALLIDUM AND SYPHILIS : II. SPIROCHÆTICIDAL ANTIBODIES AGAINST TREPONEMA PALLIDUM. Zinsser, Hans Hopkins, J. G. Article We believe that our experiments have shown that the serum of rabbits and sheep immunized with cultures of Treponema pallidum acquires spirochæticidal properties for these culture spirochætes. The normal serum of these animals also possesses spirochæticidal action if used in sufficient quantities, and the action of the immune serum represents probably an increase of the antibodies normally present. Both normal and immune spirochæticidal properties are destroyed by heating to 56°C. The spirochæticidal action of the immune serum can be reactivated by the addition of fresh normal serum of the same species, insufficient in amount to exert a spirochæticidal effect by itself. The structure of these spirochæticidal bodies, therefore, is entirely analogous to that of the well known bactericidal antibodies known to exist in antibacterial sera. We do not wish to have these results interpreted as applying to virulent spirochætes as well as to culture spirochætes. A subsequent publication will demonstrate why we specify this at present. The Rockefeller University Press 1916-03-01 /pmc/articles/PMC2125427/ /pubmed/19867990 Text en Copyright © Copyright, 1916, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Zinsser, Hans Hopkins, J. G.
spellingShingle	Zinsser, Hans Hopkins, J. G. STUDIES ON TREPONEMA PALLIDUM AND SYPHILIS : II. SPIROCHÆTICIDAL ANTIBODIES AGAINST TREPONEMA PALLIDUM.
author_facet	Zinsser, Hans Hopkins, J. G.
author_sort	Zinsser, Hans
title	STUDIES ON TREPONEMA PALLIDUM AND SYPHILIS : II. SPIROCHÆTICIDAL ANTIBODIES AGAINST TREPONEMA PALLIDUM.
title_short	STUDIES ON TREPONEMA PALLIDUM AND SYPHILIS : II. SPIROCHÆTICIDAL ANTIBODIES AGAINST TREPONEMA PALLIDUM.
title_full	STUDIES ON TREPONEMA PALLIDUM AND SYPHILIS : II. SPIROCHÆTICIDAL ANTIBODIES AGAINST TREPONEMA PALLIDUM.
title_fullStr	STUDIES ON TREPONEMA PALLIDUM AND SYPHILIS : II. SPIROCHÆTICIDAL ANTIBODIES AGAINST TREPONEMA PALLIDUM.
title_full_unstemmed	STUDIES ON TREPONEMA PALLIDUM AND SYPHILIS : II. SPIROCHÆTICIDAL ANTIBODIES AGAINST TREPONEMA PALLIDUM.
title_sort	studies on treponema pallidum and syphilis : ii. spirochæticidal antibodies against treponema pallidum.
description	We believe that our experiments have shown that the serum of rabbits and sheep immunized with cultures of Treponema pallidum acquires spirochæticidal properties for these culture spirochætes. The normal serum of these animals also possesses spirochæticidal action if used in sufficient quantities, and the action of the immune serum represents probably an increase of the antibodies normally present. Both normal and immune spirochæticidal properties are destroyed by heating to 56°C. The spirochæticidal action of the immune serum can be reactivated by the addition of fresh normal serum of the same species, insufficient in amount to exert a spirochæticidal effect by itself. The structure of these spirochæticidal bodies, therefore, is entirely analogous to that of the well known bactericidal antibodies known to exist in antibacterial sera. We do not wish to have these results interpreted as applying to virulent spirochætes as well as to culture spirochætes. A subsequent publication will demonstrate why we specify this at present.
publisher	The Rockefeller University Press
publishDate	1916
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125427/
_version_	1611416941676724224

STUDIES ON TREPONEMA PALLIDUM AND SYPHILIS : II. SPIROCHÆTICIDAL ANTIBODIES AGAINST TREPONEMA PALLIDUM.

Similar Items