THE FUNCTION OF THE SPLEEN IN THE EXPERIMENTAL INFECTION OF ALBINO MICE WITH BACILLUS TUBERCULOSIS : SECOND PAPER.

THE FUNCTION OF THE SPLEEN IN THE EXPERIMENTAL INFECTION OF ALBINO MICE WITH BACILLUS TUBERCULOSIS : SECOND PAPER.

The resistance to an infection with the tubercle bacillus which can be given to mice by the removal of the spleen is lost when fresh spleen, either of mouse or sheep, is added to the diet. The logical conclusion that splenic function in its relation to the specific infection is restored by feeding...

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Main Authors: Lewis, Paul A., Margot, Arthur Georges
Format: Online
Language:English
Published: The Rockefeller University Press 1915
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125266/
id pubmed-2125266
recordtype oai_dc
spelling pubmed-21252662008-04-18 THE FUNCTION OF THE SPLEEN IN THE EXPERIMENTAL INFECTION OF ALBINO MICE WITH BACILLUS TUBERCULOSIS : SECOND PAPER. Lewis, Paul A. Margot, Arthur Georges Article The resistance to an infection with the tubercle bacillus which can be given to mice by the removal of the spleen is lost when fresh spleen, either of mouse or sheep, is added to the diet. The logical conclusion that splenic function in its relation to the specific infection is restored by feeding spleen cannot, however, be drawn; because, in the first place, the character of the disease in the splenectomized spleen-fed animals differs somewhat from that in intact animals; and, secondly, because fresh spleen when fed to splenectomized animals apparently gives rise to an acute intoxication. This intoxication occurs quite regularly in mice. It is manifested in the infected animals and in those not inoculated. It has been seen in one of two splenectomized dogs experimented upon. Up to the present it can hardly be definitely characterized, but it seems to be best marked out by the specific anorexia associated with it. The Rockefeller University Press 1915-01-01 /pmc/articles/PMC2125266/ /pubmed/19867852 Text en Copyright © Copyright, 1915, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Lewis, Paul A.
Margot, Arthur Georges
spellingShingle Lewis, Paul A.
Margot, Arthur Georges
THE FUNCTION OF THE SPLEEN IN THE EXPERIMENTAL INFECTION OF ALBINO MICE WITH BACILLUS TUBERCULOSIS : SECOND PAPER.
author_facet Lewis, Paul A.
Margot, Arthur Georges
author_sort Lewis, Paul A.
title THE FUNCTION OF THE SPLEEN IN THE EXPERIMENTAL INFECTION OF ALBINO MICE WITH BACILLUS TUBERCULOSIS : SECOND PAPER.
title_short THE FUNCTION OF THE SPLEEN IN THE EXPERIMENTAL INFECTION OF ALBINO MICE WITH BACILLUS TUBERCULOSIS : SECOND PAPER.
title_full THE FUNCTION OF THE SPLEEN IN THE EXPERIMENTAL INFECTION OF ALBINO MICE WITH BACILLUS TUBERCULOSIS : SECOND PAPER.
title_fullStr THE FUNCTION OF THE SPLEEN IN THE EXPERIMENTAL INFECTION OF ALBINO MICE WITH BACILLUS TUBERCULOSIS : SECOND PAPER.
title_full_unstemmed THE FUNCTION OF THE SPLEEN IN THE EXPERIMENTAL INFECTION OF ALBINO MICE WITH BACILLUS TUBERCULOSIS : SECOND PAPER.
title_sort function of the spleen in the experimental infection of albino mice with bacillus tuberculosis : second paper.
description The resistance to an infection with the tubercle bacillus which can be given to mice by the removal of the spleen is lost when fresh spleen, either of mouse or sheep, is added to the diet. The logical conclusion that splenic function in its relation to the specific infection is restored by feeding spleen cannot, however, be drawn; because, in the first place, the character of the disease in the splenectomized spleen-fed animals differs somewhat from that in intact animals; and, secondly, because fresh spleen when fed to splenectomized animals apparently gives rise to an acute intoxication. This intoxication occurs quite regularly in mice. It is manifested in the infected animals and in those not inoculated. It has been seen in one of two splenectomized dogs experimented upon. Up to the present it can hardly be definitely characterized, but it seems to be best marked out by the specific anorexia associated with it.
publisher The Rockefeller University Press
publishDate 1915
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125266/
_version_ 1611416847157035008

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