THE EFFECT OF HEMATIN ON THE CIRCULATION AND RESPIRATION

1. Doses of less than six milligrams of hematin and, under certain conditions, larger doses may cause a slight rise of blood pressure. 2. Large doses of hematin cause a profound and prolonged fall of blood pressure. The principal factor in this fall of blood pressure is the marked dilatation of the...

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Main Authors:	Brown, Wade H., Loevenhart, A. S.
Format:	Online
Language:	English
Published:	The Rockefeller University Press 1913
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125121/

id	pubmed-2125121
recordtype	oai_dc
spelling	pubmed-21251212008-04-18 THE EFFECT OF HEMATIN ON THE CIRCULATION AND RESPIRATION Brown, Wade H. Loevenhart, A. S. Article 1. Doses of less than six milligrams of hematin and, under certain conditions, larger doses may cause a slight rise of blood pressure. 2. Large doses of hematin cause a profound and prolonged fall of blood pressure. The principal factor in this fall of blood pressure is the marked dilatation of the splanchnic vessels. The splanchnic dilatation either does not occur at all or but very slightly if the splanchnic nerves are cut. The splanchnic dilatation is partly compensated for by a marked constriction of cutaneous vessels and it seems probable that the cutaneous constriction is active and not simply passive to the splanchnic engorgement. 3. Hematin acts upon the cardio-inhibitory center causing a marked slowing of the rate of heart-beat, and in large doses produces a typical vagal pulse or even marked irregularities in the amplitude and rhythm of the pulse. Under hematin the heart at first shows great loss of tone but later the tone increases beyond the normal. The cardiac output for a time is greatly diminished. 4. In the large doses employed by us, hematin depresses the respiratory center and death under hematin is due to paralysis of this center. The Rockefeller University Press 1913-07-01 /pmc/articles/PMC2125121/ /pubmed/19867680 Text en Copyright © Copyright, 1913, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Brown, Wade H. Loevenhart, A. S.
spellingShingle	Brown, Wade H. Loevenhart, A. S. THE EFFECT OF HEMATIN ON THE CIRCULATION AND RESPIRATION
author_facet	Brown, Wade H. Loevenhart, A. S.
author_sort	Brown, Wade H.
title	THE EFFECT OF HEMATIN ON THE CIRCULATION AND RESPIRATION
title_short	THE EFFECT OF HEMATIN ON THE CIRCULATION AND RESPIRATION
title_full	THE EFFECT OF HEMATIN ON THE CIRCULATION AND RESPIRATION
title_fullStr	THE EFFECT OF HEMATIN ON THE CIRCULATION AND RESPIRATION
title_full_unstemmed	THE EFFECT OF HEMATIN ON THE CIRCULATION AND RESPIRATION
title_sort	effect of hematin on the circulation and respiration
description	1. Doses of less than six milligrams of hematin and, under certain conditions, larger doses may cause a slight rise of blood pressure. 2. Large doses of hematin cause a profound and prolonged fall of blood pressure. The principal factor in this fall of blood pressure is the marked dilatation of the splanchnic vessels. The splanchnic dilatation either does not occur at all or but very slightly if the splanchnic nerves are cut. The splanchnic dilatation is partly compensated for by a marked constriction of cutaneous vessels and it seems probable that the cutaneous constriction is active and not simply passive to the splanchnic engorgement. 3. Hematin acts upon the cardio-inhibitory center causing a marked slowing of the rate of heart-beat, and in large doses produces a typical vagal pulse or even marked irregularities in the amplitude and rhythm of the pulse. Under hematin the heart at first shows great loss of tone but later the tone increases beyond the normal. The cardiac output for a time is greatly diminished. 4. In the large doses employed by us, hematin depresses the respiratory center and death under hematin is due to paralysis of this center.
publisher	The Rockefeller University Press
publishDate	1913
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125121/
_version_	1611416760468111360

THE EFFECT OF HEMATIN ON THE CIRCULATION AND RESPIRATION

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