MALARIAL PIGMENT (HEMATIN) AS AN ACTIVE FACTOR IN THE PRODUCTION OF THE BLOOD PICTURE OF MALARIA

1. Intravenous injections of alkaline hematin in the rabbit produce an anemia the severity of which is proportional to the amount of hematin injected and the susceptibility of the animal. 2. Hemoglobinemia is an occasional consequence of hematin poisoning. 3. The leucocytes in hematin intoxication...

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Main Author:	Brown, Wade H.
Format:	Online
Language:	English
Published:	The Rockefeller University Press 1913
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125119/

id	pubmed-2125119
recordtype	oai_dc
spelling	pubmed-21251192008-04-18 MALARIAL PIGMENT (HEMATIN) AS AN ACTIVE FACTOR IN THE PRODUCTION OF THE BLOOD PICTURE OF MALARIA Brown, Wade H. Article 1. Intravenous injections of alkaline hematin in the rabbit produce an anemia the severity of which is proportional to the amount of hematin injected and the susceptibility of the animal. 2. Hemoglobinemia is an occasional consequence of hematin poisoning. 3. The leucocytes in hematin intoxication are usually increased in number and are always characterized by a high percentage of large mononuclear cells and by pigmented phagocytes. 4. The platelets are markedly reduced by alkaline hematin and ultimately a prolongation of the coagulation time of the blood and of the bleeding time results. 5. The anemia, the hemoglobinemia, the high percentage of large mononuclear leucocytes, the destruction of platelets, and the tendency to hemorrhage in malaria are all influenced by the malarial pigment, hematin. The Rockefeller University Press 1913-07-01 /pmc/articles/PMC2125119/ /pubmed/19867688 Text en Copyright © Copyright, 1913, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Brown, Wade H.
spellingShingle	Brown, Wade H. MALARIAL PIGMENT (HEMATIN) AS AN ACTIVE FACTOR IN THE PRODUCTION OF THE BLOOD PICTURE OF MALARIA
author_facet	Brown, Wade H.
author_sort	Brown, Wade H.
title	MALARIAL PIGMENT (HEMATIN) AS AN ACTIVE FACTOR IN THE PRODUCTION OF THE BLOOD PICTURE OF MALARIA
title_short	MALARIAL PIGMENT (HEMATIN) AS AN ACTIVE FACTOR IN THE PRODUCTION OF THE BLOOD PICTURE OF MALARIA
title_full	MALARIAL PIGMENT (HEMATIN) AS AN ACTIVE FACTOR IN THE PRODUCTION OF THE BLOOD PICTURE OF MALARIA
title_fullStr	MALARIAL PIGMENT (HEMATIN) AS AN ACTIVE FACTOR IN THE PRODUCTION OF THE BLOOD PICTURE OF MALARIA
title_full_unstemmed	MALARIAL PIGMENT (HEMATIN) AS AN ACTIVE FACTOR IN THE PRODUCTION OF THE BLOOD PICTURE OF MALARIA
title_sort	malarial pigment (hematin) as an active factor in the production of the blood picture of malaria
description	1. Intravenous injections of alkaline hematin in the rabbit produce an anemia the severity of which is proportional to the amount of hematin injected and the susceptibility of the animal. 2. Hemoglobinemia is an occasional consequence of hematin poisoning. 3. The leucocytes in hematin intoxication are usually increased in number and are always characterized by a high percentage of large mononuclear cells and by pigmented phagocytes. 4. The platelets are markedly reduced by alkaline hematin and ultimately a prolongation of the coagulation time of the blood and of the bleeding time results. 5. The anemia, the hemoglobinemia, the high percentage of large mononuclear leucocytes, the destruction of platelets, and the tendency to hemorrhage in malaria are all influenced by the malarial pigment, hematin.
publisher	The Rockefeller University Press
publishDate	1913
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125119/
_version_	1611416759239180288

MALARIAL PIGMENT (HEMATIN) AS AN ACTIVE FACTOR IN THE PRODUCTION OF THE BLOOD PICTURE OF MALARIA

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