HNF4 and HNF1 as well as a panel of hepatic functions are extinguished and reexpressed in parallel in chromosomally reduced rat hepatoma-human fibroblast hybrids
Rat hepatoma-human fibroblast hybrids of two independent lineages containing only 8-11 human chromosomes show pleiotropic extinction of thirteen out of fifteen hepatic functions examined. Reexpression of the entire group of functions most often occurs in a block, and except for one discordant subclo...
| Format: | Online |
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| Language: | English |
| Published: |
The Rockefeller University Press
1993
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119800/ |