A subset of dendritic cells induces CD4+ T cells to produce IFN-γ by an IL-12–independent but CD70-dependent mechanism in vivo

A subset of dendritic cells induces CD4+ T cells to produce IFN-γ by an IL-12–independent but CD70-dependent mechanism in vivo

Interferon (IFN)-γ, a cytokine critical for resistance to infection and tumors, is produced by CD4+ helper T lymphocytes after stimulation by cultured dendritic cells (DCs) that secrete a cofactor, interleukin (IL)-12. We have identified a major IL-12–independent pathway whereby DCs induce IFN-γ–sec...

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Bibliographic Details
Main Authors: Soares, Helena, Waechter, HaeNa, Glaichenhaus, Nicholas, Mougneau, Evelyne, Yagita, Hideo, Mizenina, Olga, Dudziak, Diana, Nussenzweig, Michel C., Steinman, Ralph M.
Format: Online
Language:English
Published: The Rockefeller University Press 2007
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118574/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118574/

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