Molecular mechanism of mast cell–mediated innate defense against endothelin and snake venom sarafotoxin

Mast cells are protective against snake venom sarafotoxins that belong to the endothelin (ET) peptide family. The molecular mechanism underlying this recently recognized innate defense pathway is unknown, but secretory granule proteases have been invoked. To specifically disrupt a single protease fu...

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Bibliographic Details
Main Authors: Schneider, Lars A., Schlenner, Susan M., Feyerabend, Thorsten B., Wunderlin, Markus, Rodewald, Hans-Reimer
Format: Online
Language:English
Published: The Rockefeller University Press 2007
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118486/