Mechanism of thioamide drug action against tuberculosis and leprosy

Thioamide drugs, ethionamide (ETH) and prothionamide (PTH), are clinically effective in the treatment of Mycobacterium tuberculosis, M. leprae, and M. avium complex infections. Although generally considered second-line drugs for tuberculosis, their use has increased considerably as the number of mul...

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Bibliographic Details
Main Authors: Wang, Feng, Langley, Robert, Gulten, Gulcin, Dover, Lynn G., Besra, Gurdyal S., Jacobs, William R., Sacchettini, James C.
Format: Online
Language:English
Published: The Rockefeller University Press 2007
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118422/