A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression

Toll-like receptors (TLRs) function as primary sensors that elicit coordinated innate immune defenses through recognition of microbial products and induction of immune and proinflammatory genes. Here we report the identification and biological characterization of a lipopolysaccharide (LPS)-like mole...

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Bibliographic Details
Main Authors: Macagno, Annalisa, Molteni, Monica, Rinaldi, Andrea, Bertoni, Francesco, Lanzavecchia, Antonio, Rossetti, Carlo, Sallusto, Federica
Format: Online
Language:English
Published: The Rockefeller University Press 2006
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118317/