Constraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virus

The predictability of virus–host interactions and disease progression in rapidly evolving human viral infections has been difficult to assess because of host and genetic viral diversity. Here we examined adaptive HIV-specific cellular and humoral immune responses and viral evolution in adult monozyg...

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Main Authors:	Draenert, Rika, Allen, Todd M., Liu, Yang, Wrin, Terri, Chappey, Colombe, Verrill, Cori L., Sirera, Guillem, Eldridge, Robert L., Lahaie, Matthew P., Ruiz, Lidia, Clotet, Bonaventura, Petropoulos, Christos J., Walker, Bruce D., Martinez-Picado, Javier
Format:	Online
Language:	English
Published:	The Rockefeller University Press 2006
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118231/

id	pubmed-2118231
recordtype	oai_dc
spelling	pubmed-21182312007-12-13 Constraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virus Draenert, Rika Allen, Todd M. Liu, Yang Wrin, Terri Chappey, Colombe Verrill, Cori L. Sirera, Guillem Eldridge, Robert L. Lahaie, Matthew P. Ruiz, Lidia Clotet, Bonaventura Petropoulos, Christos J. Walker, Bruce D. Martinez-Picado, Javier Articles The predictability of virus–host interactions and disease progression in rapidly evolving human viral infections has been difficult to assess because of host and genetic viral diversity. Here we examined adaptive HIV-specific cellular and humoral immune responses and viral evolution in adult monozygotic twins simultaneously infected with the same virus. CD4 T cell counts and viral loads followed similar trajectories over three years of follow up. The initial CD8 T cell response targeted 17 epitopes, 15 of which were identical in each twin, including two immunodominant responses. By 36 months after infection, 14 of 15 initial responses were still detectable in both, whereas all new responses were subdominant and remained so. Of four responses that declined in both twins, three demonstrated mutations at the same residue. In addition, the evolving antibody responses cross-neutralized the other twin's virus, with similar changes in the pattern of evolution in the envelope gene. These results reveal considerable concordance of adaptive cellular and humoral immune responses and HIV evolution in the same genetic environment, suggesting constraints on mutational pathways to HIV immune escape. The Rockefeller University Press 2006-03-20 /pmc/articles/PMC2118231/ /pubmed/16533886 http://dx.doi.org/10.1084/jem.20052116 Text en Copyright © 2006, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Draenert, Rika Allen, Todd M. Liu, Yang Wrin, Terri Chappey, Colombe Verrill, Cori L. Sirera, Guillem Eldridge, Robert L. Lahaie, Matthew P. Ruiz, Lidia Clotet, Bonaventura Petropoulos, Christos J. Walker, Bruce D. Martinez-Picado, Javier
spellingShingle	Draenert, Rika Allen, Todd M. Liu, Yang Wrin, Terri Chappey, Colombe Verrill, Cori L. Sirera, Guillem Eldridge, Robert L. Lahaie, Matthew P. Ruiz, Lidia Clotet, Bonaventura Petropoulos, Christos J. Walker, Bruce D. Martinez-Picado, Javier Constraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virus
author_facet	Draenert, Rika Allen, Todd M. Liu, Yang Wrin, Terri Chappey, Colombe Verrill, Cori L. Sirera, Guillem Eldridge, Robert L. Lahaie, Matthew P. Ruiz, Lidia Clotet, Bonaventura Petropoulos, Christos J. Walker, Bruce D. Martinez-Picado, Javier
author_sort	Draenert, Rika
title	Constraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virus
title_short	Constraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virus
title_full	Constraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virus
title_fullStr	Constraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virus
title_full_unstemmed	Constraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virus
title_sort	constraints on hiv-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virus
description	The predictability of virus–host interactions and disease progression in rapidly evolving human viral infections has been difficult to assess because of host and genetic viral diversity. Here we examined adaptive HIV-specific cellular and humoral immune responses and viral evolution in adult monozygotic twins simultaneously infected with the same virus. CD4 T cell counts and viral loads followed similar trajectories over three years of follow up. The initial CD8 T cell response targeted 17 epitopes, 15 of which were identical in each twin, including two immunodominant responses. By 36 months after infection, 14 of 15 initial responses were still detectable in both, whereas all new responses were subdominant and remained so. Of four responses that declined in both twins, three demonstrated mutations at the same residue. In addition, the evolving antibody responses cross-neutralized the other twin's virus, with similar changes in the pattern of evolution in the envelope gene. These results reveal considerable concordance of adaptive cellular and humoral immune responses and HIV evolution in the same genetic environment, suggesting constraints on mutational pathways to HIV immune escape.
publisher	The Rockefeller University Press
publishDate	2006
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118231/
_version_	1611414638070595584

Constraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virus

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