Human antibodies induce arthritis in mice deficient in the low-affinity inhibitory IgG receptor FcγRIIB

Rheumatoid arthritis (RA) is a complex autoimmune disease with a poorly understood pathogenesis. The disease is associated with polyclonal B cell activation and the production of autoantibodies (autoAbs), but there is a longstanding controversy as to whether such Abs contribute to, or are secondary...

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Bibliographic Details
Main Authors: Petkova, Stefka B., Konstantinov, Konstantin N., Sproule, Thomas J., Lyons, Bonnie L., Awwami, Moheeb Al, Roopenian, Derry C.
Format: Online
Language:English
Published: The Rockefeller University Press 2006
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118221/