Deregulated Syk inhibits differentiation and induces growth factor–independent proliferation of pre–B cells

Deregulated Syk inhibits differentiation and induces growth factor–independent proliferation of pre–B cells

The nonreceptor protein spleen tyrosine kinase (Syk) is a key mediator of signal transduction in a variety of cell types, including B lymphocytes. We show that deregulated Syk activity allows growth factor–independent proliferation and transforms bone marrow–derived pre–B cells that are then able to...

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Bibliographic Details
Main Authors: Wossning, Thomas, Herzog, Sebastian, Köhler, Fabian, Meixlsperger, Sonja, Kulathu, Yogesh, Mittler, Gerhard, Abe, Akihiro, Fuchs, Uta, Borkhardt, Arndt, Jumaa, Hassan
Format: Online
Language:English
Published: The Rockefeller University Press 2006
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118175/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118175/

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